| 1920 | Announcement of the first professors at the faculty, Bohumil Kužma elected as the first dean |
| 1921 | Classes at the faculty begin |
| 1922 | Biological Centre of Czech Universities in Brno established in Lednice |
| 1926 | Graduation of the first honorary doctorate at the faculty awarded to František Vejdovský |
| 1931 | Opening of a new building for the Institute of Analytical Chemistry |
| 1933 | Proposal of the parliamentary economy and controlling commission to close down the Faculty of Science and the Faculty of Arts at MU |
| 1934 | Association of Czechoslovak Students in Brno demonstrate against the intended closure of the faculties at Masaryk University |
| 1935 | Vladimír Úlehla (Institute of Plant Physiology) shoots a film series Plant Moves using collecting technology – classic artwork of Czech scientific cinematography |
| 1939 | Faculty closed down by occupying forces, the site comes under the control of the German powers in Brno |
| 1939-1945 | One-fourth of the teachers from the faculty perish as a result of Nazi persecution |
| 1945 | Classes at the faculty resume |
| 1945 | Faculty allocated the building on Janáček Square 2a |
| 1945 | Study programme of pharmacy introduced at the faculty |
| 1947 | Ceremonial unveiling of a memorial at the faculty for the victims of Nazi persecution |
| 1949 | 28 percent of the students from the 2nd – 4th years expelled due an initiative to verify student results |
| 1950 | Establishment of departments according to the Soviet model |
| 1962 | Study field structure of the faculty designated |
| 1964 | Summer School of Set Theory and General Algebra organized for the first time (later called School of Algebra and Ordered Sets) |
| 1968 | Research Institute of Computer Science established |
| 1969-1971 | During a period of consolidation 21 employees of the faculty made redundant |
| 1980 | Research Institute of Computer Science removed from the faculty and becomes the University Institute |
| 1997 | New greenhouses opened in the Botanical Garden |
| 2001 | National Centre for Biomolecular Research established |
| 2005 | New building of the Information Centre at the faculty finished |
