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Project details

Specific ion effects for proteins in solutions and related biologically relevant systems

Project Identification:	GA203/08/0114
Project Period:	1/2008 - 12/2012
Investor:	Czech Science Foundation
Programme / Project Type:	Standard Projects -
MU Faculty/Unit:	Faculty of Science MU Investigator: Prof. Mgr. Jiří Damborský, Dr. Project Team Member: Mgr. Radka Chaloupková, Ph.D. Assoc. Prof. RNDr. Zbyněk Prokop, Ph.D.
Cooperating Organization:	Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i. Responsible Person: Doc. Mgr. Pavel Jungwirth, CSc. Institute of Physical Biology USB České Budějovice Responsible Person: Doc. RNDr. Rüdiger Ettrich, Ph.D. J. Heyrovský Institute of Physical Chemistry of the ASCR, v. v. i. Responsible Person: Assoc. Prof. Martin Hof, Dr. University of South Bohemia České Budějovice
Field:	CE - Biochemistry (C - Chemistry) BO - Biophysics (B - Physics and mathematics) CF - Physical chemistry and theoretical chemistry (C - Chemistry)
Publications/Results:	more
Keywords:	salt ions, enzymatic reactions, membranes, molecular dynamics, fluorescence spectroscopy

The mechanism of hydration of ions and interaction of ions with biomolecules play an important role in many natural and biotechnological processes. We plan within this proposal to combine computational and experimental tools with the aim to obtain a fundamental molecular understanding of these reactions. We will focus on ion specific interactions with proteins in aqueous and non-aqueous solutions and at lipid membranes. Carefully designed molecular dynamics simulations and experiments will allow us in the end to formulate general rules for interactions of biologically relevant ions with solvated proteins and membranes, as well as rationalize ion effects on the activity of enzymes.