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Platinum(V) Complex with Adamantylamine as Nonleaving Amine Group: Synthesis, Characterization, and in Vitro Antitumor Activity against a Panel of Cisplatin-Resistant Cancer Cell Lines

Basic information
Original title:Platinum(V) Complex with Adamantylamine as Nonleaving Amine Group: Synthesis, Characterization, and in Vitro Antitumor Activity against a Panel of Cisplatin-Resistant Cancer Cell Lines
Authors:František Žák, Jaroslav Turánek, Aleš Kroutil, Petr Sova, Adolf Mistr, Anna Poulová, Petr Mikolin, Zdirad Žák, Andrea Kašná, Dana Záluská, Jiří Neča, Lenka Šindlerová, Alois Kozubík
Further information
Citation:ŽÁK, František, Jaroslav TURÁNEK, Aleš KROUTIL, Petr SOVA, Adolf MISTR, Anna POULOVÁ, Petr MIKOLIN, Zdirad ŽÁK, Andrea KAŠNÁ, Dana ZÁLUSKÁ, Jiří NEČA, Lenka ŠINDLEROVÁ and Alois KOZUBÍK. Platinum(V) Complex with Adamantylamine as Nonleaving Amine Group: Synthesis, Characterization, and in Vitro Antitumor Activity against a Panel of Cisplatin-Resistant Cancer Cell Lines (Platinum(V) Complex with Adamantylamine as Nonleaving Amine Group: Synthesis, Characterization, and in Vitro Antitumor Activity against a Panel of Cisplatin-Resistant Cancer Cell Lines). Journal Medicinal Chemistry, USA: USA, 2004, vol. 2004, No 47, p. 461-463. ISSN 0022-2623.Export BibTeX
@article{639612,
author = {Žák, František and Turánek, Jaroslav and Kroutil, Aleš and Sova, Petr and Mistr, Adolf and Poulová, Anna and Mikolin, Petr and Žák, Zdirad and Kašná, Andrea and Záluská, Dana and Neča, Jiří and Šindlerová, Lenka and Kozubík, Alois},
article_location = {USA},
article_number = {47},
keywords = {Platinum(V) Complex with Adamantylamine as Nonleaving Amine Group},
language = {eng},
issn = {0022-2623},
journal = {Journal Medicinal Chemistry},
title = {Platinum(V) Complex with Adamantylamine as Nonleaving Amine Group: Synthesis, Characterization, and in Vitro Antitumor Activity against a Panel of Cisplatin-Resistant Cancer Cell Lines},
volume = {2004},
year = {2004}
}
Original language:English
Field:Immunology
Type:Article in Periodical
Keywords:Platinum(V) Complex with Adamantylamine as Nonleaving Amine Group

Procedure of the synthesis is dedescribed for new platinum(V) drug LA-12 [(OC-6-43)-bis-(acetato)(1-adamantylamine)amminedichloroplatinum(IV)]. The X-ray diffraction analysis shows that the structure is created by molecules with octahedral arrangement of ligands around a platinum atom and contains one H2O molecule that is not a part of the coordination sphere of platinum.

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