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Platinum(V) Complex with Adamantylamine as Nonleaving Amine Group: Synthesis, Characterization, and in Vitro Antitumor Activity against a Panel of Cisplatin-Resistant Cancer Cell Lines

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Original title:Platinum(V) Complex with Adamantylamine as Nonleaving Amine Group: Synthesis, Characterization, and in Vitro Antitumor Activity against a Panel of Cisplatin-Resistant Cancer Cell Lines
Authors:František Žák, Jaroslav Turánek, Aleš Kroutil, Petr Sova, Adolf Mistr, Anna Poulová, Petr Mikolin, Zdirad Žák, Andrea Kašná, Dana Záluská, Jiří Neča, Lenka Šindlerová, Alois Kozubík
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Original language:English
Field:Immunology
Type:Article in Periodical
Keywords:Platinum(V) Complex with Adamantylamine as Nonleaving Amine Group

Procedure of the synthesis is dedescribed for new platinum(V) drug LA-12 [(OC-6-43)-bis-(acetato)(1-adamantylamine)amminedichloroplatinum(IV)]. The X-ray diffraction analysis shows that the structure is created by molecules with octahedral arrangement of ligands around a platinum atom and contains one H2O molecule that is not a part of the coordination sphere of platinum.

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