Publication details
Chromosome location, genomic organization of the porcine COL10A1 gene and model structure of the NC1 domain.
| Basic information | |
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| Original title: | Chromosome location, genomic organization of the porcine COL10A1 gene and model structure of the NC1 domain. |
| Authors: | L Madsen, A Petersen, V Nielsen, P Nissen, Morten Duno, Lumír Krejčí, Christian Bendixen, Bo Thomsen |
| Further information | |
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| Citation: | MADSEN, L, A PETERSEN, V NIELSEN, P NISSEN, Morten DUNO, Lumír
KREJČÍ, Christian BENDIXEN and Bo THOMSEN. Chromosome location,
genomic organization of the porcine COL10A1 gene and model
structure of the NC1 domain. (Chromosome location, genomic
organization of the porcine COL10A1 gene and model structure of
the NC1 domain.). Cytogenet Genome Res., Basel, 2003, vol. 102,
1 -4, p. 173-8. ISSN 1424-8581.Export BibTeX@article{708600, author = {Madsen, L and Petersen, A and Nielsen, V and Nissen, P and Duno, Morten and Krejčí, Lumír and Bendixen, Christian and Thomsen, Bo}, article_location = {Basel}, article_number = {1 -4},language = {eng}, issn = {1424 -8581},journal = {Cytogenet Genome Res.}, title = {Chromosome location, genomic organization of the porcine COL10A1 gene and model structure of the NC1 domain.}, url = {http://content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalAims&ProduktNr=224037}, volume = {102}, year = {2003} } |
| Original language: | English |
| Field: | Genetics and molecular biology |
| WWW: |  http://content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalAims&ProduktNr=224037 |
| Type: | Article in Periodical |
The porcine COL10A1 gene, encoding the alpha1(X) chain of type X collagen, has been sequenced. The gene structure is evolutionarily conserved, consisting of three exons and two introns spanning 7100 bp. Linkage mapping localized the gene to chromosome 1, which is in agreement with human-pig homology maps. Furthermore, protein structure comparison of the functionally important carboxyl domain between species revealed that amino acid changes were few and mainly situated in loop regions.
