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Apolipoprotein E genotype and traumatic brain injury in children—association with neurological outcome

Basic information
Original title:Apolipoprotein E genotype and traumatic brain injury in children—association with neurological outcome
Authors:Eva Brichtová, Libor Kozák
Further information
Citation:BRICHTOVÁ, Eva and Libor KOZÁK. Apolipoprotein E genotype and traumatic brain injury in children—association with neurological outcome. Childs Nerv Syst, 2007, vol. 24, No 3, p. 349-356. ISSN 0256-7040.Export BibTeX
@article{927808,
author = {Brichtová, Eva and Kozák, Libor},
article_number = {3},
keywords = {Brain injuries Child Apolipoprotein E4 Association Glasgow Coma Scale Glasgow Outcome Scale},
language = {eng},
issn = {0256-7040},
journal = {Childs Nerv Syst},
title = {Apolipoprotein E genotype and traumatic brain injury in children—association with neurological outcome},
volume = {24},
year = {2007}
}
Original language:English
Field:Neurology, neurosurgery, neurosciences
Type:Article in Periodical
Keywords:Brain injuries Child Apolipoprotein E4 Association Glasgow Coma Scale Glasgow Outcome Scale

To determine whether the presence of Apolipoprotein E 4 genotype (ApoE 4) is associated with outcomes of traumatic brain injury in children. The ApoE genotype was examined in the group of 70 pediatric patients who suffered from traumatic brain injury. The group consists of 48 boys and 22 girls, and the most frequent was the E3 isoform of ApoE. Polymerase chain reaction/restriction fragment length polymorphism method was used for the ApoE genotype assessment. Our results suggest the association between the ApoE genotype and outcome of traumatic brain injury in children. Patients with ApoE 4 genotype were more likely to have severe clinical symptomatology and unfavorable neurological outcome after traumatic brain injury compared to significantly better outcome with other ApoE genotype.

 
 
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