Informace o projektu
Propojení funkce Sprouty s FGF a primárními ciliemi ve vývoji
- Kód projektu
- GA21-04178S
- Období řešení
- 1/2021 - 12/2023
- Investor / Programový rámec / typ projektu
-
Grantová agentura ČR
- Standardní projekty
- Fakulta / Pracoviště MU
- Přírodovědecká fakulta
- Spolupracující organizace
-
Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
Univerzita Karlova v Praze
- Odpovědná osoba prof. Abigail Tucker
Sprouty proteins provide a control mechanism for appropriate receptor tyrosine kinase signaling, including FGF signaling pathway. Deficiencies in mouse Sprouties cause developmental abnormalities leading to hearing impairment, craniofacial defects, retarded postnatal growth or esophageal achalasia and intestinal pseudo-obstruction. In human, Sprouty2 has been identified to play a role in nephropathy, thanatophoric dysplasia and different types of cancer. Interestingly, fibroblast growth factor (FGF) signaling hyperactivation
syndromes and syndromes associated with primary cilia dysfunction share a range of common phenotypic manifestations, beside others, craniofacial and achondroplasia malformations. The project aims to characterize Sprouty proteins role during process of skeletogenesis. Further, we will analyze mouse model with deletion of Sprouty2 and Sprouty 4 to determine tissues and
organs developmental defects implicated in ciliopathies and evaluate primary cilia associated signaling during morphogenesis in Sprouty deficient mice.
Publikace
Počet publikací: 5
2023
-
Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling
Development, rok: 2023, ročník: 150, vydání: 7, DOI
2022
-
The Development of Dentin Microstructure Is Controlled by the Type of Adjacent Epithelium
Journal of Bone and Mineral Research, rok: 2022, ročník: 37, vydání: 2, DOI
2021
-
Loss of Sprouty produces a ciliopathic skeletal phenotype in mice through elongation of primary cilia and upregulation of Hedgehog signaling
Rok: 2021, druh: Konferenční abstrakty
-
Loss of Sprouty Produces a Ciliopathic Skeletal Phenotype in Mice Through Upregulation of Hedgehog Signaling
Journal of Bone and Mineral Research, rok: 2021, ročník: 36, vydání: 11, DOI
-
Ztráta Sprouty2/4 u myší vede k ciliopatickému fenotypu
Rok: 2021, druh: Konferenční abstrakty