Informace o publikaci

Effect of atorvastatin on dynamic parameters of myocardial repolarization in healthy subjects

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TOMAN Ondřej NOVOTNÝ Tomáš ŠIŠÁKOVÁ Martina HNATKOVA Katerina ANDRŠOVÁ Irena PAŘENICA Jiří POLOCZEK Martin JENYSOVA Jarmila MANOUSKOVA Lenka ŠPINAR Jindřich MALÍK Marek

Rok publikování 2012
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of Electrocardiology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1016/j.jelectrocard.2012.06.020
Obor Kardiovaskulární nemoci včetně kardiochirurgie
Klíčová slova Atorvastatin; Myocardial repolarization; ECG
Přiložené soubory
Popis Antiarrhythmic properties of statins were suggested as a part of their pleiotropic effects. The aim of the present study was to evaluate the effects of atorvastatin on myocardial repolarization as manifested on surface electrocardiograms (ECGs) in healthy subjects. Methods and Results: Forty young healthy volunteers (20 men, 20 women) underwent a singledose double-blind 3-way crossover study of 20 and 80 mg of atorvastatin and placebo. Long-term 13-hour 12-lead ECGs were obtained in each subject and each study period starting 15 minutes before drug administration. Each study period contained 18 time-points of 5-minute durations when the subjects were in resting supine positions. Digital ECG recordings were analyzed automatically, and the results were completed blindly before statistical analyses. Dynamic parameters of myocardial repolarization and T-wave morphology descriptors were evaluated. Although some trends were observed, no significant drug-related changes in any of investigated ECG repolarization descriptors were found. Conclusion: In comparison with placebo, single doses of atorvastatin had no effect on repolarization heterogeneity in healthy subjects. The observation confirms safe profile of the drug with limited proarrhythmic potential.

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