Informace o publikaci

Detection of Borrelia burgdorferi Sensu Stricto ospC Alleles Associated with Human Lyme Borreliosis Worldwide in Non-Human-Biting Tick Ixodes affinis and Rodent Hosts in Southeastern United States

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RUDENKO Nataliia GOLOVCHENKO Maryna HÖNIG Václav MALLÁTOVÁ Nadja KRBKOVÁ Lenka MIKOLÁŠEK Peter FEDOROVA Natalia BELFIORE Natalia M. GRUBHOFFER Libor LANE Robert S. OLIVER JR. James H.

Rok publikování 2013
Druh Článek v odborném periodiku
Časopis / Zdroj Applied and Environmental Microbiology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://aem.asm.org/content/79/5/1444#ref-list-1
Doi http://dx.doi.org/10.1128/AEM.02749-12
Obor Epidemiologie, infekční nemoci a klinická imunologie
Klíčová slova Borrelia; population structure; ospC; ecology; diversity; trans-oceanic migration
Přiložené soubory
Popis Comparative analysis of ospC genes from 127 Borrelia burgdorferi sensu stricto strains collected in European and North American regions where Lyme disease is endemic and where it is not endemic revealed a close relatedness of geographically distinct populations. OspC alleles A, B, and L were detected on both continents in vectors and hosts, including humans. Six ospC alleles, A, B, L, Q, R, and V, were prevalent in Europe; 4 of them were detected in samples of human origin. Ten ospC alleles, A, B, D, E3, F, G, H, H3, I3, and M, were identified in the far-western United States. Four ospC alleles, B, G, H, and L, were abundant in the southeastern United States. Here we present the first expanded analysis of ospC alleles of B. burgdorferi strains from the southeastern United States with respect to their relatedness to strains from other North American and European localities.Wedemonstrate that ospC genotypes commonly associated with human Lyme disease in European and North American regions where the disease is endemic were detected in B. burgdorferi strains isolated from the non-human-biting tick Ixodes affinis and rodent hosts in the southeastern United States.Wediscovered that some ospC alleles previously known only from Europe are widely distributed in the southeastern United States, a finding that confirms the hypothesis of transoceanic migration of Borrelia species.

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