Informace o publikaci
New PAH derivatives functionalized by cyclic nitrone framework: Synthetic design, anti-proliferative activity and interaction with DNA
| Autoři | |
|---|---|
| Rok publikování | 2013 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Bioorganic & Medicinal Chemistry |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | http://www.sciencedirect.com/science/article/pii/S096808961300031X |
| Doi | http://dx.doi.org/10.1016/j.bmc.2013.01.004 |
| Obor | Organická chemie |
| Klíčová slova | Polycyclic aromatic hydrocarbon (PAH);Nitrones;DNA;Intercalation;Docking |
| Přiložené soubory | |
| Popis | Novel approach to functionalized polycyclic aromatic hydrocarbons (PAHs) is presented. Incorporation of cyclic nitrone framework into the structure of PAHs was studied with respect to their anti-proliferative activities and interaction with double stranded DNA. Theoretical docking studies and UV titration methods were used for preliminary evaluation of binding of new PAH derivatives to DNA structure. |
| Související projekty: |