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MicroRNAs targeting EGFR signalling pathway in colorectal cancer

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MLČOCHOVÁ Jitka FALTEJSKOVÁ Petra NĚMEČEK Radim SVOBODA Marek SLABÝ Ondřej

Rok publikování 2013
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of cancer research and clinical oncology
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www http://link.springer.com/article/10.1007%2Fs00432-013-1470-9
Doi http://dx.doi.org/10.1007/s00432-013-1470-9
Obor Onkologie a hematologie
Klíčová slova MicroRNA; Colorectal cancer; EGFR signalling pathway; Predictive biomarkers; Prognostic biomarkers
Popis MicroRNAs (miRNAs) are short, 18–25- nucleotide long, non-coding single-stranded RNAs, which are capable to regulate gene expression on post-transcrip- tional level through binding to their target protein-encoding mRNAs. miRNAs regulate individual components of multiple oncogenic pathways. One of them is epidermal growth factor receptor (EGFR) signalling pathway that regulates cell proliferation, differentiation, migration, angiogenesis and apoptosis. All these processes are deregulated in colorectal cancer (CRC). Moreover, EGFR has been validated as the therapeutic target in CRC, and monoclonal antibodies cetuximab and panitumumab are used in the therapy of patients with metastatic CRC. Because of the extensive involvement of miRNAs in the regulation of EGFR signalling, it seems they could also serve as promising predictive biomarkers to anti-EGFR therapy. In this review, we summarize current knowledge about miRNAs targeting EGFR signalling pathway, their functioning in CRC pathogenesis and potential usage as biomarkers.
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