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Chromatin dynamics of plant telomeres and ribosomal genes

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DVOŘÁČKOVÁ Martina FOJTOVÁ Miloslava FAJKUS Jiří

Rok publikování 2015
Druh Článek v odborném periodiku
Časopis / Zdroj The Plant Journal
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www http://onlinelibrary.wiley.com/doi/10.1111/tpj.12822/epdf
Doi http://dx.doi.org/10.1111/tpj.12822
Obor Genetika a molekulární biologie
Klíčová slova telomere; rDNA; Arabidopsis thaliana; Nicotiana tabacum; chromatin; epigenetics
Přiložené soubory
Popis Telomeres and genes encoding 45S ribosomal RNA (rDNA) are frequently located adjacent to each other on eukaryotic chromosomes. Although their primary roles are different, they show striking similarities with respect to their features and additional functions. Both genome domains have remarkably dynamic chromatin structures. Both are hypersensitive to dysfunctional histone chaperones, responding at the genomic and epigenomic levels. Both generate non-coding transcripts that, in addition to their epigenetic roles, may induce gross chromosomal rearrangements. Both give rise to chromosomal fragile sites, as their replication is intrinsically problematic. However, at the same time, both are essential for maintenance of genomic stability and integrity. Here we discuss the structural and functional inter-connectivity of telomeres and rDNA, with a focus on recent results obtained in plants.
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