Informace o publikaci
A novel method for heterocyclic amide–thioamide transformations
| Autoři | |
|---|---|
| Rok publikování | 2017 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Beilstein Journal of Organic Chemistry |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | https://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-13-20.pdf |
| Doi | http://dx.doi.org/10.3762/bjoc.13.20 |
| Obor | Organická chemie |
| Klíčová slova | heterocyclic amides; heterocyclic thioamides; N-cyclohexyl dithiocarbamate cyclohexylammonium salt; novel thiating agent; thiation |
| Popis | In this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles. Secondly, the chloroherocycles and N-cyclohexyl dithiocarbamate cyclohexylammonium salt were heated in chloroform for 12 h at 61 °C to afford heteocyclic thioamides in excellent yields. |