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Locally advanced breast cancer in elderly patients

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HORNOVA Jana BORTLÍČEK Zbyněk MÁJKOVÁ Petra ABRAHAMOVA Jitka KORDIKOVA Drahomira DONATOVA Zuzana KUPEC Martin BOUBLIKOVA Ludmila DVORAK Josef ZAPLETAL Radek BUCHLER Tomas

Rok publikování 2017
Druh Článek v odborném periodiku
Časopis / Zdroj Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc, Czech Republic
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.5507/bp.2017.011
Obor Onkologie a hematologie
Klíčová slova breast cancer; Charlson score; elderly; retrospective analysis; survival
Popis Background. Although locally advanced breast cancer (LABC) is more common in the elderly population, there is little data on the clinical characteristics and survival of these patients. The aim of the present study was to compare different factors affecting survival in elderly patients with LABC. Methods. Retrospective analysis was carried out on a cohort of 80 patients aged 70 to 96 years, diagnosed with LABC defined as T3 N1, T4 N0, any N2 or N3, and M0. The prognostic impact of selected clinical parameters including age, comorbidities, tumour grade, HER2 status, tumour stage, local therapies, and systemic treatments was studied. Results. The median age of the patients was 79 years. The majority (n=53; 66%) had at least one significant comorbidity according to the Charlson score evaluation. The median overall survival was 50.6 months. As expected, hormonal therapy was the dominant mode of systemic treatment, but 24% also received at least one line of chemotherapy. Local therapies including surgery and/or radiotherapy were applied in 58% of patients. Conclusions. The diagnosis of LABC in the elderly is associated with poor prognosis. Age and serious comorbidities were negative prognostic factors.

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