Pyrazolotriazines as inhibitors of nucleases

• Autoři: DAMBORSKÝ Jiří; NIKULENKOV Fedor; SISÁKOVÁ Alexandra; HAVEL Štěpán; KREJČÍ Lumír; CARBAIN Benoit, Jean-Pierre; BREZOVSKÝ Jan; DANIEL Lukáš; PARUCH Kamil
• Rok publikování: 2018
• Druh: Patent
• Fakulta / Pracoviště MU: Přírodovědecká fakulta
• Vydavatel: Japan Patent Office
• Stát vydání: Japonsko
• Číslo patentu: JP 6313906
• www: https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=JP&NR=6313906B2&KC=B2&FT=D&ND=&date=20180418&DB=&locale=#
• Popis: The present invention relates to substituted heterocycles as inhibitors of nudeases MUS81 and MRE11, pharmaceutical compositions containing the compounds, and pharmaceutical use of the compounds and compositions in the treatment of the diseases such as, for example, cancer.

Související projekty

• Development of new MUS81 nuclease inhibitors as chemical biology probe with clinical progression
• CZ-­OPENSCREEN: National Infrastructure for Chemical Biology