Informace o publikaci

Silk route to the acceptance and re-implementation of bacteriophage therapy - part II

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SYBESMA Wilbert ROHDE Christine BÁRDY Pavol PIRNAY Jean-Paul COOPER Ian CAPLIN Jonathan CHANISHVILI Nina COFFEY Aidan DE VOS Daniel SCHOLZ Amber Hartman MCCALLIN Shawna PÜSCHNER Hilke Marie PANTŮČEK Roman AMINOV Rustam DOŠKAŘ Jiří KURTBÖKE Ipek D.

Rok publikování 2018
Druh Článek v odborném periodiku
Časopis / Zdroj Antibiotics-Basel
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://www.mdpi.com/2079-6382/7/2/35
Doi http://dx.doi.org/10.3390/antibiotics7020035
Klíčová slova antibiotic resistance; bacteriophages; bacteriophage therapy; Nagoya Protocol; CRISPR CAS
Přiložené soubory
Popis This perspective paper follows up on earlier communications on bacteriophage therapy that we wrote as a multidisciplinary and intercontinental expert-panel when we first met at a bacteriophage conference hosted by the Eliava Institute in Tbilisi, Georgia in 2015. In the context of a society that is confronted with an ever-increasing number of antibiotic-resistant bacteria, we build on the previously made recommendations and specifically address how the Nagoya Protocol might impact the further development of bacteriophage therapy. By reviewing a number of recently conducted case studies with bacteriophages involving patients with bacterial infections that could no longer be successfully treated by regular antibiotic therapy, we again stress the urgency and significance of the development of international guidelines and frameworks that might facilitate the legal and effective application of bacteriophage therapy by physicians and the receiving patients. Additionally, we list and comment on several recently started and ongoing clinical studies, including highly desired double-blind placebo-controlled randomized clinical trials. We conclude with an outlook on how recently developed DNA editing technologies are expected to further control and enhance the efficient application of bacteriophages.

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