Informace o publikaci

Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review

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PELTANOVÁ Barbora RAUDENSKÁ Martina MASAŘÍK Michal

Rok publikování 2019
Druh Článek v odborném periodiku
Časopis / Zdroj Molecular Cancer
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://dx.doi.org/10.1186/s12943-019-0983-5
Doi http://dx.doi.org/10.1186/s12943-019-0983-5
Klíčová slova Tumor microenvironment; Head and neck cancer; Tumor metabolism; Epithelial-mesenchymal transition
Popis The tumor microenvironment (TME) is comprised of many different cell populations, such as cancer-associated fibroblasts and various infiltrating immune cells, and non-cell components of extracellular matrix. These crucial parts of the surrounding stroma can function as both positive and negative regulators of all hallmarks of cancer development, including evasion of apoptosis, induction of angiogenesis, deregulation of the energy metabolism, resistance to the immune detection and destruction, and activation of invasion and metastasis. This review represents a summary of recent studies focusing on describing these effects of microenvironment on initiation and progression of the head and neck squamous cell carcinoma, focusing on oral squamous cell carcinoma, since it is becoming clear that an investigation of differences in stromal composition of the head and neck squamous cell carcinoma microenvironment and their impact on cancer development and progression may help better understand the mechanisms behind different responses to therapy and help define possible targets for clinical intervention.
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