Informace o publikaci

Short stature in a boy with atypical progeria syndrome due to LMNA c.433G > A [p.(Glu145Lys)]: apparent growth hormone deficiency but poor response to growth hormone therapy

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TONI Ledjona DUŠÁTKOVÁ Petra NOVOTNÁ Dana ZEMKOVÁ Daniela PRŮHOVÁ Štěpánka LEBL Jan

Rok publikování 2019
Druh Článek v odborném periodiku
Časopis / Zdroj JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://dx.doi.org/10.1515/jpem-2019-0107
Doi http://dx.doi.org/10.1515/jpem-2019-0107
Klíčová slova atypical progeria syndrome; growth hormone deficiency; LMNA
Popis Background: Hutchinson-Gilford progeria syndrome (HGPS) is a rare disease caused by pathogenic variants in the LMNA gene, which leads to premature aging. The median life expectancy is shortened to 13 years due to cardiovascular complications. Case report: We present a boy born with a pathogenic LMNA variant c.A33G > A, which causes atypical progeria syndrome (APS) and was previously described in one single patient. When investigated for poor growth prior to the diagnosis of APS, his laboratory tests revealed growth hormone (GH) deficiency and magnetic resonance imaging (MRI) of the midbrain showed partial empty sella. Gil treatment had only a limited and transient effect. His first ischemic complication manifested at age 4.2 years; at the age of 7 years, he had a fatal haemorrhagic stroke. Conclusion: To the best of our knowledge, this is the first patient with APS showing partial empty sella and GH deficiency that might have contributed to his poor growth. Gil failed to improve long-term outcome.

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