Informace o publikaci

Safety of recombinant human C1 esterase inhibitor for hereditary angioedema attacks during pregnancy

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MOLDOVAN Dumitru BERNSTEIN Jonathan A. HAKL Roman POREBSKI Grzegorz POARCH Kimberly LUMRY William R. RELAN Anurag

Rok publikování 2019
Druh Článek v odborném periodiku
Časopis / Zdroj JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
Fakulta / Pracoviště MU

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Citace
www http://dx.doi.org/10.1016/j.jaip.2019.05.042
Doi http://dx.doi.org/10.1016/j.jaip.2019.05.042
Klíčová slova C1-INHIBITOR CONCENTRATE
Popis Hereditary angioedema (HAE) is a rare (<1 in 50,000) ge-netic disorder characterized by episodes of cutaneous andmucosal angioedema. HAE is caused by insufficient suppressionof complement and contact-system cascades due to a deficiencyof functional C1 inhibitor (C1-INH). It has been demonstratedthat HAE abdominal attacks are more frequent during preg-nancy, but there is no consensus on which trimester is mostassociated with increased attack rates.Some data suggest thatmore severe attacks and symptoms occur during thefirsttrimester, whereas other data suggest a greater number of attacksin the second and third trimesters. Changes in hormone levelsduring pregnancy may exacerbate HAE attacks, and concernswith administration of certain medications during pregnancy cancomplicate HAE management.

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