Informace o publikaci
Divergent distributions of inverted repeats and G-quadruplex forming sequences in Saccharomyces cerevisiae
| Autoři | |
|---|---|
| Rok publikování | 2020 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Genomics |
| Citace | |
| www | https://www.sciencedirect.com/science/article/pii/S0888754319305269 |
| Doi | http://dx.doi.org/10.1016/j.ygeno.2019.11.002 |
| Klíčová slova | G-quadruplex; Inverted repeat; Saccharomyces cerevisiae |
| Popis | The importance of DNA structure in the regulation of basic cellular processes is an emerging field of research. Among local non-B DNA structures, inverted repeat (IR) sequences that form cruciforms and G-rich sequences that form G-quadruplexes (G4) are found in all prokaryotic and eukaryotic organisms and are targets for regulatory proteins. We analyzed IRs and G4 sequences in the genome of the most important biotechnology microorganism, S. cerevisiae. IR and G4-prone sequences are enriched in specific genomic locations and differ markedly between mitochondrial and nuclear DNA. While G4s are overrepresented in telomeres and regions surrounding tRNAs, IRs are most enriched in centromeres, rDNA, replication origins and surrounding tRNAs. Mitochondrial DNA is enriched in both IR and G4-prone sequences relative to the nuclear genome. This extensive analysis of local DNA structures adds to the emerging picture of their importance in genome maintenance, DNA replication and transcription of subsets of genes. |