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Integration of Cryo-EM Model Building Software in Scipion

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MARTÍNEZ Marta JIMÉNEZ-MORENO Amaya MALUENDA David RAMÍREZ-APORTELA Erney MELERO Roberto CUERVO Ana CONESA Pablo DEL CANO Laura FONSECA Yunior SÁNCHEZ-GARCÍA Ruben STŘELÁK David CONESA Javier FERNÁNDEZ-GIMÉNEZ Estrella DE ISIDRO Federico SORZANO Carlos CARAZO Jose Maria MARABINI Roberto

Rok publikování 2020
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of Chemical Information and Modeling
Fakulta / Pracoviště MU

Ústav výpočetní techniky

Citace
www http://dx.doi.org/10.1021/acs.jcim.9b01032
Doi http://dx.doi.org/10.1021/acs.jcim.9b01032
Klíčová slova ELECTRON-MICROSCOPY; LOCAL RESOLUTION; VALIDATION TOOLS; VISUALIZATION; MAPS
Popis Advances in cryo-electron microscopy (cryo-EM) have made it possible to obtain structures of large biological macromolecules at near-atomic resolution. This "resolution revolution" has encouraged the use and development of modeling tools able to produce high-quality atomic models from cryo-EM density maps. Unfortunately, many practical problems appear when combining different packages in the same processing workflow, which make difficult the use of these tools by non-experts and, therefore, reduce their utility. We present here a major extension of the image processing framework Scipion that provides inter-package integration in the model building area and full tracking of the complete workflow, from image processing to structure validation.
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