Anti-alpha gal antibodies in the context of blood group and stool and tumour-adjacent microbiome in colorectal cancer patients

• Autoři: SELINGEROVA I.; BUDINSKÁ Eva; ZWINSOVÁ Barbora; MAZALOVA B.; BENCSIKOVA B.; VALIK D.; DUBSKA L.Z.
• Rok publikování: 2019
• Druh: Konferenční abstrakty
• Fakulta / Pracoviště MU: Přírodovědecká fakulta
• Popis: Gut microbiome plays a role in the development and clinical course of colorectal cancer (CRC). Natural antibodies against galactose-a-1,3-galactose (a-gal) are highly abundant in humans due to regular stimulation from gut bacteria. Similarly, Abs against AB0 blood group antigens are produced as cross-reacting with intestinal bacteria and a-gal epitope has similar structure to blood group B Ag. Blood group antigens may be associated with an expansion families of gut bacteria.