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The Emerging Role of Noncoding RNAs in Pediatric Inflammatory Bowel Disease

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JABANDŽIEV Petr BOHOŠOVÁ Júlia PINKASOVÁ Tereza KUNOVSKÝ Lumír SLABÝ Ondřej GOEL Ajay

Rok publikování 2020
Druh Článek v odborném periodiku
Časopis / Zdroj Inflammatory Bowel Diseases
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://academic.oup.com/ibdjournal/article/26/7/985/5721205
Doi http://dx.doi.org/10.1093/ibd/izaa009
Klíčová slova pediatrics; inflammatory bowel disease; Crohn’s disease; ulcerative colitis; noncoding RNA; microRNA
Popis Prevalence of inflammatory bowel disease (IBD), a chronic inflammatory disorder of the gut, has been on the rise in recent years—not only in the adult population but also especially in pediatric patients. Despite the absence of curative treatments, current therapeutic options are able to achieve long-term remission in a significant proportion of cases. To this end, however, there is a need for biomarkers enabling accurate diagnosis, prognosis, and prediction of response to therapies to facilitate a more individualized approach to pediatric IBD patients. In recent years, evidence has continued to evolve concerning noncoding RNAs (ncRNAs) and their roles as integral factors in key immune-related cellular pathways. Specific deregulation patterns of ncRNAs have been linked to pathogenesis of various diseases, including pediatric IBD. In this article, we provide an overview of current knowledge on ncRNAs, their altered expression profiles in pediatric IBD patients, and how these are emerging as potentially valuable clinical biomarkers as we enter an era of personalized medicine.

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