Informace o publikaci

Trop2: Jack of All Trades, Master of None

Logo poskytovatele
Logo poskytovatele
Logo poskytovatele
Autoři

LENÁRT Sára LENÁRT Peter ŠMARDA Jan REMŠÍK Ján SOUČEK Karel BENEŠ Petr

Rok publikování 2020
Druh Článek v odborném periodiku
Časopis / Zdroj Cancers
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://doi.org/10.3390/cancers12113328
Doi http://dx.doi.org/10.3390/cancers12113328
Klíčová slova Trop2; TACSTD2; cancer; proliferation; metastases; epithelial-to-mesenchymal transition; therapy
Přiložené soubory
Popis Trophoblast cell surface antigen 2 (Trop2) is a widely expressed glycoprotein and an epithelial cell adhesion molecule (EpCAM) family member. Although initially identified as a transmembrane protein, other subcellular localizations and processed forms were described. Its congenital mutations cause a gelatinous drop-like corneal dystrophy, a disease characterized by loss of barrier function in corneal epithelial cells. Trop2 is considered a stem cell marker and its expression associates with regenerative capacity in various tissues. Trop2 overexpression was described in tumors of different origins; however, functional studies revealed both oncogenic and tumor suppressor roles. Nevertheless, therapeutic potential of Trop2 was recognized and clinical studies with drug-antibody conjugates have been initiated in various cancer types. One of these agents, sacituzumab govitecan, has been recently granted an accelerated approval for therapy of metastatic triple-negative breast cancer. In this article, we review the current knowledge about the yet controversial function of Trop2 in homeostasis and pathology.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info