Informace o publikaci

Childhood cancer epidemiology in the Czech Republic (1994–2016)

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KREJČÍ Denisa ZAPLETALOVÁ Michaela KATINOVÁ Ivana BAJČIOVÁ Viera MÚDRY Peter ŠMELHAUS Vratislav ŠTĚRBA Jaroslav STARÝ Jan CAPOCACCIA Riccardo DUŠEK Ladislav

Rok publikování 2020
Druh Článek v odborném periodiku
Časopis / Zdroj Cancer Epidemiology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.sciencedirect.com/science/article/abs/pii/S187778212030182X?via%3Dihub
Doi http://dx.doi.org/10.1016/j.canep.2020.101848
Klíčová slova childhood cancer; incidence; mortality; survival; czech republic
Popis Background: The knowledge of cancer burden in the population, its time trends and the possibility of international comparison is an important starting point for cancer control programmes. Our study aimed to evaluate trends in childhood cancer epidemiology of patients aged 0–14 years in the period 1994–2016 in the Czech Republic. Methods: Data on childhood cancers have been obtained from the Czech National Cancer Registry. These data were validated using the clinical database of childhood cancer patients and combined with data from death certificates. Incidence and mortality trends were assessed by the joinpoint regression method. The life tables method was used to calculate the overall age-standardised five-year survival. Results: The incidence trend was stable; the age-standardised (world) cancer incidence – ASR (W) – was 173.7 per 1 million children in the period 1994–2016. However, there was apparent significant decrease in mortality: ASR (W) dropped from 58.1 per 1 million children in 1994 to 21.4 per 1 million children in 2016. The overall fiveyear survival increased over time by 10 %. Statistically significant improvements in survival were observed in patients with lymphoid leukaemia, astrocytomas, neuroblastomas, osteosarcomas and rhabdomyosarcomas. Conclusion: Such a relevant increase in survival rates, and therefore also a decrease in mortality rates in the Czech Republic, is most likely due to improvements in diagnostic and treatment methods since the 1990s, which were facilitated by the concentration of childhood cancer patients in children’s cancer centres.
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