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Maytenus macrocarpa (Ruiz & Pav.) Briq.: Phytochemistry and Pharmacological Activity

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MALANÍK Milan TREML Jakub RJAŠKOVÁ Veronika TÍŽKOVÁ Karolína KAUCKÁ Petra KOKOŠKA Ladislav KUBATKA Peter ŠMEJKAL Karel

Rok publikování 2019
Druh Článek v odborném periodiku
Časopis / Zdroj Molecules
Fakulta / Pracoviště MU

Farmaceutická fakulta

Citace
Doi http://dx.doi.org/10.3390/molecules24122288
Klíčová slova dihydro-beta-agarofuran sesquiterpene; folk medicine; Maytenus macrocarpa; rheumatism; triterpene
Popis Maytenus macrocarpa (Celastraceae) is a tree native to Amazonia. Its roots, leaves, bark, and combinations of these are used in traditional medicine mainly to treat rheumatism and, to a lesser extent, to heal wounds and to combat bronchitis and diarrhea. To date, mainly triterpenes and dihydro-beta-agarofuran sesquiterpenes were isolated from M. macrocarpa. Extracts and selected pure compounds isolated from the leaves, roots, and stem bark showed antibacterial, antiviral, antiparasitic, anti-inflammatory, and cytotoxic activities in vitro. The aim of this review is to summarize the available ethnobotanical, phytochemical, and pharmacological information about this traditional Amazonian medicinal tree, as well as to attract the attention of phytochemists and pharmacognosists to this potentially interesting source of ethnopharmaceuticals.

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