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Spindle Cell Hemangioma and Atypically Localized Juxtaglomerular Cell Tumor in a Patient with Hereditary BRIP1 Mutation: A Case Report

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PAPEŽ Jan ŠTARHA Jiří ZERHAU Pavel PAVLOVSKÁ Denisa JEŽOVÁ Marta JUŘENČÁK Tomáš SLABÁ Kateřina ŠTĚRBA Martin KEREKES Arpád MERTA Tomáš HALUŠKOVÁ Terézia PÁLOVÁ Hana SLABÝ Ondřej ŠTĚRBA Jaroslav JABANDŽIEV Petr

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj Genes
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.mdpi.com/2073-4425/12/2/220
Doi http://dx.doi.org/10.3390/genes12020220
Klíčová slova juxtaglomerular cell tumor; reninoma; spindle cell hemangioendothelioma; kidney; hypertension; children
Popis Spindle cell hemangioma is a benign vascular tumor typically occurring in the dermis or subcutis of distal extremities as red–brown lesions that can grow in both size and number over time. They can be very painful and potentially disabling. A family history of cancer or previous history may be relevant and must be taken into consideration. Juxtaglomerular cell tumor (reninoma) is an extremely rare cause of secondary hypertension diagnosed mostly among adolescents and young adults. Excessive renin secretion results in secondary hyperaldosteronism. Subsequent hypokalemia and metabolic alkalosis, together with high blood pressure, are clues for clinical diagnosis. Histological examination of the excised tumor leads to a definitive diagnosis. Reninoma is found in subcapsular localization, in most cases as a solitary mass, in imaging studies of kidneys. Exceptionally, it can be located in another part of a kidney. Both spindle cell hemangioma and reninoma are extremely rare tumors in children and adolescents. Herein, the authors present a case report of a patient with hereditary BRCA1 interacting protein C-terminal helicase 1 (BRIP1) mutation, spindle cell hemangioma, and secondary hypertension caused by atypically localized reninoma.
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