Informace o publikaci

Contemporary clinical neurophysiology applications in dystonia

Autoři

KANOVSKY Petr ROSALES Raymond OTRUBA Pavel NEVRLY Martin HVIZDOSOVA Lenka OPAVSKY Robert KAISEROVA Michaela HOK Pavel MENSIKOVA Katerina HLUSTIK Petr BAREŠ Martin

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of Neural Transmission
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://link.springer.com/article/10.1007/s00702-021-02310-6
Doi http://dx.doi.org/10.1007/s00702-021-02310-6
Klíčová slova Dystonia; Neurophysiology; Network disorder; Brain plasticity
Popis The complex phenomenological understanding of dystonia has transcended from the clinics to genetics, imaging and neurophysiology. One way in which electrophysiology will impact into the clinics are cases wherein a dystonic clinical presentation may not be typical or a "forme fruste" of the disorder. Indeed, the physiological imprints of dystonia are present regardless of its clinical manifestation. Underpinnings in the understanding of dystonia span from the peripheral, segmental and suprasegmental levels to the cortex, and various electrophysiological tests have been applied in the course of time to elucidate the origin of dystonia pathophysiology. While loss of inhibition remains to be the key finding in this regard, intricacies and variabilities exist, thus leading to a notion that perhaps dystonia should best be gleaned as network disorder. Interestingly, the complex process has now spanned towards the understanding in terms of networks related to the cerebellar circuitry and the neuroplasticity. What is evolving towards a better and cohesive view will be neurophysiology attributes combined with structural dynamic imaging. Such a sound approach will significantly lead to better therapeutic modalities in the future.

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info