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Aggressive systemic mastocytosis with diffuse bone marrow (18) F-FDG uptake

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KOUKALOVÁ Renata VAŠINA Jiří ŠTIKA Jiří DOUBEK Michael SZTURZ Petr

Rok publikování 2022
Druh Článek v odborném periodiku
Časopis / Zdroj Nuklearmedizin-Nuclear Medicine
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1650-9704
Doi http://dx.doi.org/10.1055/a-1650-9704
Klíčová slova mastocytosis; positron emission tomography; computed tomography; KIT D816V mutation; osteopenia; osteosclerosis
Popis Mastocytosis is a clonal hematopoietic disorder characterized by proliferation of abnormal mast cells in various organs including the skin, digestive system, lymph nodes, and bone marrow. We report on a 75-year-old woman presenting with abdominal pain, vomiting, diarrhoea, myalgia, and weight loss. Abdominal CT showed hepatosplenomegaly with heterogeneous splenic parenchyma, lymphadenopathy, and osteopenia with areas of osteosclerosis but no primary tumour. An 18F-FDG PET/CT revealed an overall low metabolic activity of the lesions with a diffuse bone marrow involvement raising suspicion of a haematological neoplasm. Subsequently, bone marrow and peripheral blood examinations confirmed the diagnosis of aggressive systemic mastocytosis.

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