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Metabolic tricks of cancer cells

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HÖNIGOVÁ Kateřina NAVRÁTIL Jiří PELTANOVÁ Barbora HOLCOVÁ POLANSKÁ Hana RAUDENSKÁ Martina MASAŘÍK Michal

Rok publikování 2022
Druh Článek v odborném periodiku
Časopis / Zdroj Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.sciencedirect.com/science/article/pii/S0304419X22000300
Doi http://dx.doi.org/10.1016/j.bbcan.2022.188705
Klíčová slova Cancer metabolism; ;Warburg effect; Glutaminolysis; Mitochondrial bioenergetics; Metabolic symbiosis; Cell death
Popis One of the characteristics of cancer cells important for tumorigenesis is their metabolic plasticity. Indeed, in various stress conditions, cancer cells can reshape their metabolic pathways to support the increased energy request due to continuous growth and rapid proliferation. Moreover, selective pressures in the tumor microenvironment, such as hypoxia, acidosis, and competition for resources, force cancer cells to adapt by complete reorganization of their metabolism. In this review, we highlight the characteristics of cancer metabolism and discuss its clinical significance, since overcoming metabolic plasticity of cancer cells is a key objective of modern cancer therapeutics and a better understanding of metabolic reprogramming may lead to the identification of possible targets for cancer therapy.
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