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FASTER THROMBOLYSIS IN VIVO

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BRHELOVÁ Eliška OPATŘILOVÁ Radka SCHEER Peter HLOŽKOVÁ Jana THALEROVÁ Sandra AKSU Ahmet Davut MIKULÍK Robert

Rok publikování 2023
Druh Konferenční abstrakty
Fakulta / Pracoviště MU

Farmaceutická fakulta

Citace
Popis This innovative experimental work focuses on the development of targeted thrombolytics combinations for the diagnosis and therapy of cerebral infarction, their preparation and testing in a rat animal model. The effect of the addition of plasminogen to the standard recombinant alteplase in the treatment of cerebral infarction was tested. A rat model of systemic embolism was used for this purpose. The design of the model is set to simulate as much as possible the course of thrombolysis in the human organism and the implementation of preclinical research into clinical practice is realistic.
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