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Heat shock proteins in cancer - Known but always being rediscovered: Their perspectives in cancer immunotherapy

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MAZURAKOVA Alena SOLAROVA Zuzana KOKLESOVA Lenka CAPRNDA Martin PROSECKÝ Robert KHAKYMOV Artur BARANENKO Denis KUBATKA Peter MIROSSAY Ladislav KRUŽLIAK Peter SOLAR Peter

Rok publikování 2023
Druh Článek v odborném periodiku
Časopis / Zdroj Advances in Medical Sciences
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.sciencedirect.com/science/article/pii/S1896112623000457?via%3Dihub
Doi http://dx.doi.org/10.1016/j.advms.2023.10.005
Klíčová slova HSPs; Cancer; Anti-Cancer therapy; Immunotherapy; Immunomodulation
Popis Heat shock proteins (HSPs) represent cellular chaperones that are classified into several families, including HSP27, HSP40, HSP60, HSP70, and HSP90. The role of HSPs in the cell includes the facilitation of protein folding and maintaining protein structure. Both processes play crucial roles during stress conditions in the cell such as heat shock, degradation, and hypoxia. Moreover, HSPs are important modulators of cellular proliferation and differentiation, and are strongly associated with the molecular orchestration of carcinogenesis. The expression and/or activity of HSPs in cancer cells is generally abnormally high and is associated with increased metastatic potential and activity of cancer stem cells, more pronounced angiogenesis, downregulated apoptosis, and the resistance to anticancer therapy in many patients. Based on the mentioned reasons, HSPs have strong potential as valid diagnostic, prognostic, and therapeutic biomarkers in clinical oncology. In addition, numerous papers describe the role of HSPs as chaperones in the regulation of immune responses inside and outside the cell. Importantly, highly expressed/activated HSPs may be inhibited via immunotherapeutic targets in various types of cancers. The aim of this work is to provide a comprehensive overview of the relationship between HSPs and the tumor cell with the intention of highlighting the potential use of HSPs in personalized cancer management.

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