Informace o publikaci
Stereoselective synthesis of alpha-alkylidene- and substituted alkylidene-gamma-lactones
| Autoři | |
|---|---|
| Rok publikování | 2000 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Tetrahedron Letters |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | http://www.elsevier.nl/inca/publications/store/2/3/3/ |
| Obor | Organická chemie |
| Klíčová slova | methylene lactones; coupling reactions; palladium; zinc compounds |
| Popis | Cross-coupling reactions of (E)- and (Z)-tosylates of alpha-hydroxymethylene-gamma-butyrolactone with aryl, heteroaryl, alkyl, and alkynylzinc chlorides under Pd(PPh3)4 catalysis were found to be a suitable synthetic method for stereoselective preparation of alpha-alkylidene- and substituted alkylidene-gamma-lactones. Reactions, conducted under mild conditions, proceed with high stereoselectivity and moderate yields. |
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