Informace o publikaci
Modification of natural, double-helical DNA by antitumor cis- and trans-[Cl2(Me2SO4)4Ru] in cell-free media
| Autoři | |
|---|---|
| Rok publikování | 2000 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Biochemical Pharmacology |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Biofyzika |
| Popis | Modifications of natural DNA in cell-free media by antitumor ruthenium compounds, cis- and trans-[Cl2(Me2SO4)4Ru] were studied by various biochemical and biophysical methods. The results indicated that both ruthenium compounds irreversibly coordinated to DNA. Several features of DNA binding mode of trans-[Cl2(Me2SO4)4Ru] were similar to those of antitumor cisplatin, which may be relevant to biological effects of this antitumor ruthenium drug. On the other hand, the different DNA binding mode of cis-[Cl2(Me2SO4)4Ru] was consistent with its less pronounced biological effects. |