Informace o publikaci

Dynamics of CYP2D6 activity and clinical response to paroxetine, alprazolam and their combination in patients with depressive disorder

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HADAŠOVÁ Eva ŽOURKOVÁ Alexandra TOMANDL Josef RAVČUKOVÁ Barbora

Rok publikování 2003
Druh Článek v odborném periodiku
Časopis / Zdroj Chemické listy
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor Farmakologie a lékárnická chemie
Klíčová slova Genetic polymorphism; CYP2D6; paroxetine; alprazolam; psychiatric patients
Popis Dynamics of the paroxetine-induced inhibition of CYP2D6 was followed during the paroxetine therapy in patients using phenotyping and genotyping methods. Another aim of the study was to evaluate the level of the enzyme restoration after discontinuation of the paroxetine treatment. The study has shown that even a profound inhibition of CYP2D6 activity in patients without mutation in the CYP2D6 locus had only minor clinical relevance for treatment effectivity and occurence of adverse effects.
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