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Variability in CNR1 locus influences protein intake and smoking status in the Central-European population

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BIENERTOVÁ VAŠKŮ Julie BIENERT Petr SLOVÁČKOVÁ Lenka SÁBLÍKOVÁ Lenka PISKÁČKOVÁ Zlata FOREJT Martin ŠPLÍCHAL Zbyněk ZLÁMAL Filip VAŠKŮ Anna

Rok publikování 2012
Druh Článek v odborném periodiku
Časopis / Zdroj Nutritional Neuroscience
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1179/1476830512Y.0000000001
Obor Ostatní lékařské obory
Klíčová slova Endocannabinoids; SNP; Dietary composition; Macronutrients; Gene
Přiložené soubory
Popis Objectives: The endocannabinoid receptor 1 (CB1) is encoded by the CNR1 gene and has been recently recognized to play an important role in the regulation of satiety and feeding behaviour with a huge potential of modulating metabolic response and feeding control. The aim of the study was to investigate the potential of three selected single nucleotide polymorphisms (SNPs) in the CNR1 locus on native dietary composition in the Central-European Caucasian population. Methods: A total of 258 unrelated individuals originating from the Central-European Caucasian population were enrolled into the study and rs1049353, rs12720071, and rs806368 polymorphisms in CNR1 locus were examined in these individuals using PCR-based methodology. Body composition was assessed using a bioimpedance method, various anthropometric parameters were investigated (waist and hip circumference, skin folds), and native dietary composition was analysed using 7-day food records as well as a food frequency questionnaire. Results: Allelic variations and common haplotypes in the CNR1 gene were associated with the daily intake of proteins, fluids, and fibre, regardless of the physical activity of the individuals. The common haplotype in the CNR1 gene was associated with self-reported smoking (number of cigarettes per day, smoking years). Discussion: Our results indicate that specific genetic variations in the CNR1 gene may act as susceptibility markers for specific dietary composition in the Central-European population.

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