POSTDOC POSITION in Bioinformatics in Stem Cell Neurobiology

Medical Faculty of Masaryk University, Brno, Czech Republic, invites excellent scientists to apply for a two-year

POSTDOC POSITION in Bioinformatics in Stem Cell Neurobiology

Description:

Our Neurobiology group uses cellular models (human induced pluripotent stem cells) to study Alzheimer's disease (AD) pathogenesis in vitro. Our in vitro models include a large portfolio of neuronal cell systems, including 2D neurons and 3D cerebral organoids. We aim to study, and ultimately to understand, the mechanisms of AD initiation and potential treatment for AD.

We focus on mechanisms of neuronal differentiation, cellular senescence, metabolism, endosomal trafficking, and pathogen infections and how these processes influence the pathobiology of AD.

Our research is hypothesis-driven, and we seek to complement our analytical tools with high-throughput bulk-mRNA/miRNA seq analyses as well as single-cell seq transcriptomics to fully exploit the potential of our unique model systems.

As a part of the job, we offer participation in the relevant Bioinformatics training at EMBL-EBI or similar.

We collaborate with numerous Czech and International Laboratories, including Max Planck Institute, Germany; Aarhus University, Denmark; Amsterdam UMC, The Netherlands, and others.

Our team currently consists of 7 Post-doctoral researchers, 1 Research Scientist, 2 Ph.D. students, and 1 undergrad student, who are all proficient in their fields of expertise.
 

The successful candidate should:

• Hold a Ph.D. or its equivalent, awarded within the past 7 years.
• Have a research background that includes a minimum of 2 full years of work, within the last 3 years, in the field of research conducted outside the Czech Republic, with a workload equivalent to at least 0.5 full-time employment, or have experience as a doctoral student (or equivalent) in an international setting.
• Demonstrate a publication record that includes a minimum of three research outputs (articles) within the past three years, surpassing the field's median standards, with at least two of them ranked in Q1 according to Web of Science.

Specific qualifications include:

• Possession of a scientific degree in computational biology, bioinformatics, or closely related fields.
• A robust interest in single-cell omics, with a track record in applied NGS data analysis, particularly in transcriptomics (RNA-seq, scRNA-seq). Proficiency in other omics methods is an added advantage.
• Demonstrated expertise in programming languages essential for data analysis, including R and/or Python
• Proficiency in Linux/Unix and the ability to work with bash scripts.
• Previous experience in constructing and maintaining bioinformatics tools and pipelines is a valuable asset.
• Aptitude for proposing innovative solutions and critically evaluating data.
• Exceptional communication skills and a strong commitment to collaborative teamwork.

We offer:

• An initial two-year appointment.
• An exceptionally competitive salary, commensurate with the applicant's skills and proficiency.
• An enticing position within a rapidly evolving university precinct.
• A range of diverse and stimulating responsibilities within an outstanding research environment.
• The opportunity to collaborate with a professional team in a comfortable work environment.
• Interaction with renowned scientists within an inspiring, globally-connected setting.
• A dedicated welcome service tailored to the needs of the successful candidate and their family.

Include these in your application:

• A comprehensive CV, detailing your publication history,
• a copy of your diploma,
• contact information for two referees who can provide insights into your qualifications,
• a brief but substantive description of your research focus and the specific topic you intend to investigate. Justify the relevance of this research within the field,
• documentation confirming that you have accumulated a minimum of two full years of work experience outside the Czech Republic within the past three years, and/or a Ph.D. diploma from a foreign institution.

Anticipated start date: The position is available from April 2024 or upon agreement

The submission deadline is 31st  January 2024

How to apply:

Please use the "E-Application" link below. After submitting your application, you will receive an automatic confirmation of acceptance via email. For more information, contact Mgr. Dasa Bohaciakova, Ph.D. by e-mail: bohaciakova@med.muni.cz

Further information about:

• Medical Faculty is available at https://www.med.muni.cz/en
• Masaryk University is available at https://www.muni.cz/en
• Brno is available at https://www.gotobrno.cz/en/