RNDr. Mário Špírek, PhD.
Assistant professor, Lumír Krejčí Research Group
Office: bldg. B07/305
Kamenice 753/5
625 00 Brno
Phone: | +420 549 49 5364 |
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E‑mail: |
social and academic networks: |
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Total number of publications: 22
2024
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Physical interaction with Spo11 mediates the localisation of Mre11 to chromatin in meiosis and promotes its nuclease activity
Nucleic acids research, year: 2024, DOI
2022
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The role of bivalent ions in the regulation of D-loop extension mediated by DMC1 during meiotic recombination
iSCIENCE, year: 2022, volume: 25, edition: 11, DOI
2021
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Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function
Nature Communications, year: 2021, volume: 12, edition: 1, DOI
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Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates
Nucleic acids research, year: 2021, volume: 49, edition: 1, DOI
2020
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Antibiotic-induced DNA damage results in a controlled loss of pH homeostasis and genome instability
Scientific reports, year: 2020, volume: 10, edition: 1, DOI
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DSS1 interacts with and stimulates RAD52 to promote the repair of DSBs
Nucleic Acids Research, year: 2020, volume: 48, edition: 2, DOI
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Mussel-mimicking sulfobetaine-based copolymer with metal tunable gelation, self-healing and antibacterial capability
Arabian Journal of Chemistry, year: 2020, volume: 13, edition: 1, DOI
2018
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Human RAD51 rapidly forms intrinsically dynamic nucleoprotein filaments modulated by nucleotide binding state
Nucleic Acids Research, year: 2018, volume: 46, edition: 8, DOI
2017
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Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection
Cell Reports, year: 2017, volume: 21, edition: 2, DOI
2016
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A Polar and Nucleotide-Dependent Mechanism of Action for RAD51 Paralogs in RAD51 Filament Remodeling
Molecular Cell, year: 2016, volume: 64, edition: 5, DOI