doc. Mgr. Kamil Paruch, Ph.D.
Associate professor, Department of Chemistry
Correspondence Address:
Kotlářská 267/2, 611 37 Brno
Office: bldg. A08/322
Kamenice 753/5
625 00 Brno
Phone: | +420 549 49 5477 |
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E‑mail: |
Total number of publications: 148
2017
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INHIBITION OF CHK1 STIMULATES THE COOPERATIVE CYTOTOXIC ACTION OF PLATINUM-BASED DRUGS AND TRAIL IN HUMAN PROSTATE CANCER CELLS
Year: 2017, type: Conference abstract
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Kompletní analýza vlastností nových inhibitorů kasein kinázy 1 pro léčbu chronické lymfocytární leukémie
Year: 2017, type:
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Potenciál inhibice proteinu Chk1 u chronické lymfocytární leukémie s mutacemi v genu TP53.
Year: 2017, type: Conference abstract
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Pyrazolotriazines as inhibitors of nucleases
Publisher: European Patent Office, state: Germany, patent's number: EP2957562, year: 2017
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Structural Basis of the Interaction of Cyclin-Dependent Kinase 2 with Roscovitine and Its Analogues Having Bioisosteric Central Heterocycles
ChemPhysChem, year: 2017, volume: 18, edition: 7, DOI
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Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation
Molecular Cancer Therapeutics, year: 2017, volume: 16, edition: 9, DOI
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The role of Chk1 in regulation of apoptosis induced by platinum-based drugs in human prostate cancer cells
Year: 2017, type: Conference abstract
2016
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Development and validation of a highly sensitive LC-MS method for determination of checkpoint kinase 1 inhibitors in mouse plasma
Advances in chromatography and electrophoresis & Chiranal 2016, year: 2016
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Checkpoint kinase 1 inhibition potentiates apoptosis and inflicts mitotic failure in CLL-derived MEC-1 cell line.
Year: 2016, type: Conference abstract
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Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells
Oncotarget, year: 2016, volume: 7, edition: 38, DOI