Konstantinos Tripsianes, Ph.D.

2026

• A Wnt-induced conformational phospho-switch in DVL3 controls association with Frizzled receptors and Wnt/β-catenin signaling

  MICKA Miroslav KUMAR Jitender PACLÍKOVÁ Petra HAYEK Zuzana HANÁKOVÁ Kateřina BECHARA Cherine PLEŠINGEROVÁ Hana ŠEDO Ondrej BOLOGNA Sara DEL NERO Elise GÖMÖRYOVÁ Kristína BYSTRÝ Vojtěch GYBEĽ Tomáš ČÍHALOVÁ Tereza KRAVEC Marek POTĚŠIL David ZDRÁHAL Zbyněk TRIPSIANES Konstantinos BRYJA Vítězslav

  Peer-reviewed scientific article

  SCIENCE ADVANCES, year: 2026, volume: 12, edition: 20, DOI

• Phosphorylation of SF3B1 by CDK11 orchestrates spliceosome activation via SNIP1-dependent RES complex recruitment

  GAJDUŠKOVÁ Pavla DE LOS MOZOS Igor Ruiz HLUCHÝ Milan MYŠKOVÁ Antonina ZÁBRADY Kateřina MANÍK Peter DRAGIŠIĆ Neda HANÁKOVÁ Kateřina POTĚŠIL David BOLOGNA Sara NOVÁČEK Jiří FRIEDEL Caroline C. TRIPSIANES Konstantinos ZDRÁHAL Zbyněk BLAŽEK Dalibor

  Peer-reviewed scientific article

  NATURE COMMUNICATIONS, year: 2026, volume: 17, edition: 1, DOI

• PRICKLE3 protects VANGL proteins from CK1-mediated phosphorylation and RNF43-mediated degradation

  RADASZKIEWICZ Katarzyna Anna RADASZKIEWICZ Tomasz Witold KOLÁŘOVÁ Pavla PACLÍKOVÁ Petra GÖMÖRYOVÁ Kristína NOVOTNÁ Šárka AGOSTINI MAIA Lorena ČÍHALOVÁ Tereza LE Yao BÁRTA Tomáš HANÁKOVÁ Kateřina HÝSKOVÁ Anna TRIPSIANES Konstantinos ZDRÁHAL Zbyněk WINKLER Christoph HARNOŠ Jakub

  Peer-reviewed scientific article

  Communications Biology, year: 2026, volume: 9, edition: 1, DOI

2025

• A class III ligand oscillates between internal and terminal binding modes as it engages with the Dishevelled PDZ domain

  KUMAR Jitender MICKA Miroslav KOMÁREK Jan KLUMPLER Tomáš BYSTRÝ Vojtěch SPRANGERS Remco BARINKA Cyril BRYJA Vítězslav TRIPSIANES Konstantinos

  Peer-reviewed scientific article

  Structure, year: 2025, volume: 33, edition: 8, DOI

2024

• Carboxy-terminal polyglutamylation regulates signaling and phase separation of the Dishevelled protein

  KRAVEC Marek ŠEDO Ondrej NEDVEDOVA Jana MICKA Miroslav ŠULCOVÁ Marie ZEZULA Nikodém GÖMÖRYOVÁ Kristína POTĚŠIL David GANJI Sri Ranjani BOLOGNA Sara ČERVENKA Igor ZDRÁHAL Zbyněk HARNOŠ Jakub TRIPSIANES Konstantinos JANKE Carsten BARINKA Cyril BRYJA Vítězslav

  Peer-reviewed scientific article

  EMBO Journal, year: 2024, volume: 43, edition: 22, DOI

2023

• Recognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase

  PAPAGEORGIOU Anna POSPÍŠILOVÁ Michaela CIBULKA Jakub ASHRAF Raghib WAUDBY Christopher KADEŘÁVEK Pavel MAROZ Volha KUBÍČEK Karel PROKOP Zbyněk KREJČÍ Lumír TRIPSIANES Konstantinos

  Peer-reviewed scientific article

  Nature Communications, year: 2023, volume: 14, edition: 1, DOI

2022

• Fusion of two unrelated protein domains in a chimera protein and its 3D prediction: Justification of the x-ray reference structures as a prediction benchmark

  VYMETAL Jiri MERTOVA Katerina BOUSOVA Kristyna SULC Josef TRIPSIANES Konstantinos VONDRASEK Jiri

  Peer-reviewed scientific article

  Proteins: Structure, Function, and Bioinformatics, year: 2022, volume: 90, edition: 12, DOI

2021

• 4D-GRAPHS

  BRÁZDIL Tomáš PORTEŠ David FILIPOVIČ Jiří HOZZOVÁ Jana EVANGELIDIS Thomas TRIPSIANES Konstantinos

  Software

  Year: 2021

• 4D-CHAINS

  EVANGELIDIS Thomas TRIPSIANES Konstantinos

  Software

  Year: 2021

• Distinct EH domains of the endocytic TPLATE complex confer lipid and protein binding

  YPERMAN K. PAPAGEORGIOU Anna MERCERON R. DE MUNCK S. BLOCH Y. EECKHOUT D. JIANG Q.H. TACK P. GRIGORYAN R. EVANGELIDIS Thomas VAN LEENE J. VINCZE L. VANDENABEELE P. VANHAECKE F. POTOCKY M. DE JAEGER G. SAVVIDES S.N. TRIPSIANES Konstantinos PLESKOT R. VAN DAMME D.

  Peer-reviewed scientific article

  Nature Communications, year: 2021, volume: 12, edition: 1, DOI