RNDr. Iva Gudernová

2025

• FGFR2 residence in primary cilia is necessary for epithelial cell signaling

  NITĂ Alexandru POOVAKULATHU ABRAHAM Sara ELREFAAY Eman FAFÍLEK Bohumil ČÍŽKOVÁ Eliška URSACHI Vlad-Constantin GUDERNOVÁ Iva KOUDELKA Adolf DUDEJA Pooja GREGOR Tomáš FEKETOVÁ Zuzana RICO LLANOS Gustavo Adolfo SVOZILOVÁ Kateřina ÇELIKER Canan CZYREK Aleksandra Anna BÁRTA Tomáš TRANTÍREK Lukáš WIEDLOCHA Antoni KREJČÍ Pavel BOSÁKOVÁ Michaela

  Article in Periodical

  Journal of cell biology, year: 2025, volume: 224, edition: 7, DOI

2019

• Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase

  BOSÁKOVÁ Michaela NITĂ Alexandru GREGOR Tomáš VAŘECHA Miroslav GUDERNOVÁ Iva FAFÍLEK Bohumil BÁRTA Tomáš BASHEER Neha POOVAKULATHU ABRAHAM Sara BÁLEK Lukáš TOMANOVÁ Markéta FIALOVÁ KUČEROVÁ Jana BOSÁK Juraj POTĚŠIL David ZIEBA Jennifer SONG Jieun KONIK Peter PARK Sohyun DURAN Ivan ZDRÁHAL Zbyněk ŠMAJS David JANSEN Gert FU Zheng KO Hyuk Wan HAMPL Aleš TRANTÍREK Lukáš KRAKOW Deborah KREJČÍ Pavel

  Article in Periodical

  Proceedings of the National Academy of Sciences of the United States of America, year: 2019, volume: 116, edition: 10, DOI

2018

• Nanodiamonds as "artificial proteins": Regulation of a cell signalling system using low nanomolar solutions of inorganic nanocrystals

  BÁLEK Lukáš BUCHTOVÁ Marcela BOSÁKOVÁ Michaela VAŘECHA Miroslav TRANTÍRKOVÁ Silvie GUDERNOVÁ Iva VESELÁ Iva HAVLIK Jan NEBURKOVA Jitka TURNER Stuart KRZYSCIK Mateusz Adam ZAKRZEWSKA Malgorzata KLIMASCHEWSKI Lars CLAUS Peter TRANTÍREK Lukáš CIGLER Petr KREJČÍ Pavel

  Article in Periodical

  Biomaterials, year: 2018, volume: 176, edition: SEP 2018, DOI

• Proteomic analyses of signalling complexes associated with receptor tyrosine kinase identify novel members of fibroblast growth factor receptor 3 interactome

  BÁLEK Lukáš NĚMEC Pavel KONIK P. BOSÁKOVÁ Michaela VAŘECHA Miroslav GUDERNOVÁ Iva MEDALOVÁ Jiřina KRAKOW Deborah KREJČÍ Pavel

  Article in Periodical

  Cellular Signalling, year: 2018, volume: 42, edition: JAN 2018, DOI

• The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases

  FAFÍLEK Bohumil BÁLEK Lukáš BOSÁKOVÁ Michaela VAŘECHA Miroslav NITĂ Alexandru GREGOR Tomáš GUDERNOVÁ Iva KŘENOVÁ Jitka GHOSH S. PISKÁČEK Martin JONATOVA Lucie ČERNOHORSKÁ Nicole ZIEBA J.T. KOSTAS M. HAUGSTEN E.M. WESCHE J. ERNEUX C. TRANTÍREK Lukáš KRAKOW D. KREJČÍ Pavel

  Article in Periodical

  SCIENCE SIGNALING, year: 2018, volume: 11, edition: 548, DOI

• The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling

  CSUKASI F. DURAN I. BARAD M. BÁRTA Tomáš GUDERNOVÁ Iva TRANTÍREK Lukáš MARTIN J.H. KUO C.Y. WOODS J. LEE H. COHN D.H. KREJČÍ Pavel KRAKOW D.

  Article in Periodical

  Science Translational Medicine, year: 2018, volume: 10, edition: 459, DOI

2017

• ARQ 087 inhibits FGFR signaling and rescues aberrant cell proliferation and differentiation in experimental models of craniosynostoses and chondrodysplasias caused by activating mutations in FGFR1, FGFR2 and FGFR3

  BÁLEK Lukáš GUDERNOVÁ Iva VESELA Iva HAMPL Marek ORALOVÁ Veronika BOSÁKOVÁ Michaela VAŘECHA Miroslav NĚMEC Pavel HALL Terence ABBADESSA Giovanni HATCH Nan BUCHTOVÁ marcela KREJČÍ Pavel

  Article in Periodical

  Bone, year: 2017, volume: 105, edition: DEC 2017, DOI

• Inhibitor repurposing reveals ALK, LTK, FGFR, RET and TRK kinases as the targets of AZD1480

  GUDERNOVÁ Iva BÁLEK Lukáš VAŘECHA Miroslav FIALOVÁ KUČEROVÁ Jana BOSÁKOVÁ Michaela FAFÍLEK Bohumil PALUŠOVÁ Veronika ULDRIJAN Stjepan TRANTÍREK Lukáš KREJČÍ Pavel

  Article in Periodical

  Oncotarget, year: 2017, volume: 8, edition: 65, DOI

• One reporter for in-cell activity profiling of majority of protein kinase oncogenes

  GUDERNOVÁ Iva TRANTÍRKOVÁ Silvie EL GHANNAMOVÁ Barbora FAFÍLEK Bohumil VAŘECHA Miroslav BÁLEK Lukáš HRUBÁ Eva JONÁTOVÁ Lucie JELÍNKOVÁ Iva BOSÁKOVÁ Michaela TRANTÍREK Lukáš MAYER Jiří KREJČÍ Pavel

  Article in Periodical

  eLife, year: 2017, volume: 6, edition: "e21536", DOI

• Statins do not inhibit the FGFR signaling in chondrocytes

  FAFÍLEK Bohumil HAMPL Marek ŘIČÁNKOVÁ Nikola VESELA I. BÁLEK Lukáš BOSÁKOVÁ Michaela GUDERNOVÁ Iva VAŘECHA Miroslav BUCHTOVÁ marcela KREJČÍ Pavel

  Article in Periodical

  Osteoarthritis and Cartilage, year: 2017, volume: 25, edition: 9, DOI