PharmDr. Zdeněk Spáčil, Ph.D.

Head, Metabolomics and Targeted Proteomics


Office: bud. D29/418
Kamenice 753/5
625 00 Brno

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Phone: +420 549 49 7989
E‑mail:
CV

Curriculum Vitae

Person Identification
  • Dr. Zdeněk Spáčil
    born in Olomouc, Czech Republic
Affiliation and Address
  • Metabolomics and Proteomics Research Group
    Research Centre for Toxic Compounds in the Environment
    Faculty of Science, Masaryk University
    Kamenice 753/5, pavilion A29/418 625 00 Brno Czech Republic
Employment Position
  • Assistant professor
Education and Academic Qualifications
  • 2010: Ph.D., Department of Analytical Chemistry, Faculty of Science, Stockholm University, Stockholm, Sweden
  • 2006: MSc., Department of Analytical Chemistry, Faculty of Pharmacy, Charles University in Prague, Hradec Králové, Czech Republic
Employment Summary
  • 2018-now: Assistant professor
  • 2015-2017: Group Leader, Faculty of Science, Masaryk University, Brno, Czech Republic
  • 2014-2015: Research Scientist, University of Washington, Seattle, United States of America
  • 2012-2014: Postdoctoral Fellow, Institute for Systems Biology, Seattle, United States of America
  • 2010-2012: Research Associate, University of Washington, Seattle, United States of America
Pedagogical Activities
  • Mass Spectrometry; Separation Science; Analytical Chemistry; Clinical Chemistry; Metabolomics; Targeted Proteomics; Biomarkers
Research Projects
  • 2018-2020: The Grant Agency of the Masaryk university, GAMU project No. MUNI/G/1131/2017
  • 2017-2019: The Czech Science Foundation; GACR project No. 17-24592Y
  • 2015-2022: CETOCOEN Plus; Ministry of Education, Youth and Sports of the CR; CZ.02.1.01/0.0/0.0/15_003/0000469
  • 2013-2017: The National Institutes of Health of United States; NIH/NIDDK project R01; No. DK 067859-09
  • 2012-2014: The Bill and Melinda Gates Foundation, Global Health Grant; No. 0PP1039684
  • 2008-2009: The Charles University Grant Agency, GAUK; project No. 119308/B/2008
  • 2008: The Czech Ministry of Education, FRVS project No. 349
Academical Stays
  • 5/2014-8/2015: Research Stay; Department of Chemistry, University of Washington, Seattle, WA, United States of America
  • 2/2012-5/2014: Post-doctoral Fellowship; Institute for Systems Biology, Seattle, WA, United States of America
  • 3/2010-2/2012: Post-doctoral Fellowship; Department of Chemistry, University of Washington, Seattle, WA, United States of America
  • 9/2008-1/2010: Mobility Program of Charles University; Department of Analytical Chemistry, Stockholm University, Stockholm, Sweden
  • 9/2005-3/2006: ERASMUS Student Mobility Project; Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece
International Courses
  • 8/2018: Targeted Quantitative Proteomics Course, University of Washington, Seattle, WA, United States of America
  • 9/2017: Metabolomics Course, Mass Spectrometry Applications to the Clinical Lab (MSACL), Salzburg, Austria
  • 2/2013: Quantitative Proteomics Course, Mass Spectrometry Applications to the Clinical Lab (MSACL), San Diego, CA, United States of America
  • 9-11/2011: Biophysical Analysis, University of Washington, Seattle, WA, United States of America
  • 4-6/2011: Molecular Enzymology; University of Washington, Seattle, WA, United States of America
  • 4-6/2011: Analytical Spectroscopy; University of Washington, Seattle, WA, United States of America
Appreciation by Science Community
  • 2014-now: member of the Czech Society for Mass Spectrometry (CSMS), Palacky University, Olomouc, Czech Republic
  • 2010-now: member of the Pacific Northwest Mass Spectrometry Group (PacMass), Seattle, WA, United States of America
  • 2009-now: member of the American Society for Mass Spectrometry, Santa Fe, NM, United States of America
  • 2001-now: honorary member of the ▪ honorary member of Czech Pharmacy Students' Association, Charles University, Hradec Kralove, Czech Republic
Selected Publications
  • PAVLOVÁ, Tereza, Veronika VIDOVÁ, Julie BIENERTOVÁ VAŠKŮ, Petr JANKŮ, Martina ALMÁŠI, Jana KLÁNOVÁ a Zdeněk SPÁČIL. Urinary intermediates of tryptophan as indicators of the gut microbial metabolism. Analytica Chimica Acta, Amsterdam: Elsevier Science, 2017, roč. 987, September, s. 72-80. ISSN 0003-2670. doi:10.1016/j.aca.2017.08.022. URL info
  • LIAO, Hsuan-Chieh, Zdeněk SPÁČIL, Farideh GHOMASHCHI, Maria L. ESCOLAR, Joanne KURTZBERG, Joseph J. ORSINI, Frantisek TURECEK, C. Ronald SCOTT a Michael H. GELB. Lymphocyte Galactocerebrosidase Activity by LC-MS/MS for Post-Newborn Screening Evaluation of Krabbe Disease. Clinical Chemistry, Washington, USA: AMER ASSOC CLINICAL CHEMISTRY, 2017, roč. 63, č. 8, s. 1363-1369. ISSN 0009-9147. doi:10.1373/clinchem.2016.264952. URL info
  • VIDOVÁ, Veronika a Zdeněk SPÁČIL. A review on mass spectrometry-based quantitative proteomics: Targeted and data independent acquisition. Analytica Chimica Acta, Amsterdam: Elsevier Science publishers, 2017, roč. 964, April, s. 7-23. ISSN 0003-2670. doi:10.1016/j.aca.2017.01.059. URL info
  • SPÁČIL, Zdeněk, AB KUMAR, HC LIAO, C AURAY-BLAIS, S STARK, TR SUHR, CR SCOTT, F TURECEK a MH GELB. Sulfatide Analysis by Mass Spectrometry for Screening of Metachromatic Leukodystrophy in Dried Blood and Urine Samples. Clinical Chemistry, Washington, USA: Amer. Assoc. Clinical Chemistry, 2016, roč. 62, č. 1, s. 279-286. ISSN 0009-9147. doi:10.1373/clinchem.2015.245159. URL info
  • KUMAR, AB, Zdeněk SPÁČIL, F GHOMASHCHI, S MASI, T SUMIDA, M ITO, F TURECEK, CR SCOTT a MH GELB. Fluorimetric assays for N-acetylgalactosamine-6-sulfatase and arylsulfatase B based on the natural substrates for confirmation of mucopolysaccharidoses types IVA and VI. Clinica Chimica Acta, AMSTERDAM: ELSEVIER SCIENCE BV, 2015, roč. 451, s. 125-128. ISSN 0009-8981. doi:10.1016/j.cca.2015.08.010. URL info
  • KUMAR, AB, S MASI, F GHOMASHCHI, NK CHENNAMANENI, M ITO, CR SCOTT, F TURECEK, MH GELB a Zdeněk SPÁČIL. Tandem Mass Spectrometry Has a Larger Analytical Range than Fluorescence Assays of Lysosomal Enzymes: Application to Newborn Screening and Diagnosis of Mucopolysaccharidoses Types II, IVA, and VI. Clinical Chemistry, Washington, USA: Amer. Assoc. Clinical Chemistry, 2015, roč. 61, č. 11, s. 1363-1371. ISSN 0009-9147. doi:10.1373/clinchem.2015.242560. URL info
  • JIANG, LY, P DZIEDZIC, Zdeněk SPÁČIL, GL ZHAO, L NILSSON, LL ILAG a A CORDOVA. Abiotic synthesis of amino acids and self-crystallization under prebiotic conditions. Scientific Reports, LONDON: NATURE PUBLISHING GROUP, 2014, roč. 4. ISSN 2045-2322. doi:10.1038/srep06769. info
  • CHENNAMANENI, NK, AB KUMAR, M BARCENAS, Zdeněk SPÁČIL, CR SCOTT, F TURECEK a MH GELB. Improved Reagents for Newborn Screening of Mucopolysaccharidosis Types I, II, and VI by Tandem Mass Spectrometry. Analytical Chemistry, WASHINGTON: AMER CHEMICAL SOC, 2014, roč. 86, č. 9, s. 4508-4514. ISSN 0003-2700. doi:10.1021/ac5004135. info
  • SPÁČIL, Zdeněk, H TATIP2AKA, M BARCENAS, CR SCOTT, F TURECEK a MH GELB. High-Throughput Assay of 9 Lysosomal Enzymes for Newborn Screening. Clinical Chemistry, Washington, USA: Amer. Assoc. Clinical Chemistry, 2013, roč. 59, č. 3, s. 502-511. ISSN 0009-9147. doi:10.1373/clinchem.2012.189936. info
  • JIANG, LY, B AIGRET, Borggraeve WM DE, Zdeněk SPÁČIL a LL ILAG. Selective LC-MS/MS method for the identification of BMAA from its isomers in biological samples. Analytical and Bioanalytical chemistry, HEIDELBERG: SPRINGER HEIDELBERG, 2012, roč. 403, č. 6, s. 1719-1730. ISSN 1618-2642. doi:10.1007/s00216-012-5966-y. info
  • SPÁČIL, Zdeněk, S ELLIOTT, SL REEBER, MH GELB, CR SCOTT a F TURECEK. Comparative Triplex Tandem Mass Spectrometry Assays of Lysosomal Enzyme Activities in Dried Blood Spots Using Fast Liquid Chromatography: Application to Newborn Screening of Pompe, Fabry, and Hurler Diseases. Analytical Chemistry, WASHINGTON: AMER CHEMICAL SOC, 2011, roč. 83, č. 12, s. 4822-4828. ISSN 0003-2700. doi:10.1021/ac200417u. info
  • JONASSON, S, J ERIKSSON, L BERNTZON, Zdeněk SPÁČIL, LL ILAG, LO RONNEVI, U RASMUSSEN a B BERGMAN. Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure. Proceedings of the National Academy of Sciences of the United States of America, WASHINGTON: National Academy of Sciences, 2010, roč. 107, č. 20, s. 9252-9257. ISSN 0027-8424. doi:10.1073/pnas.0914417107. info

2018/10/04