PharmDr. Zdeněk Spáčil, Ph.D.

2026

• Real-life organochlorine mixture-induced lipid dysregulation and oxidative stress in Leydig TM3 cells: Mechanistic insights into male reprotoxicity

  VIRMANI Ishita SYCHROVÁ Eliška ŘEHŮŘKOVÁ Eliška GADARA Darshak Chandulal SPÁČIL Zdeněk NOVÁK Jiří SOVADINOVÁ Iva

  Article in Periodical

  Toxicology, year: 2026, volume: 519, edition: January 2026, DOI

2025

• 2-Ethylhexyl Diphenyl Phosphate Affects Steroidogenesis and Lipidome Profile in Human Adrenal (H295R) Cells

  NEGI Chander Kant GADARA Darshak Chandulal BAJARD ÉP.ESNER Lola Murielle SPÁČIL Zdeněk BLÁHA Luděk

  Article in Periodical

  CHEMICAL RESEARCH IN TOXICOLOGY, year: 2025, volume: 38, edition: 4, DOI

2024

• Cyanotoxin cylindrospermopsin disrupts lipid homeostasis and metabolism in a 3D in vitro model of the human liver

  ROY CHOWDHURY Riju FELIPE GROSSO Marina GADARA Darshak Chandulal SPÁČIL Zdeněk VIDOVÁ Veronika SOVADINOVÁ Iva BABICA Pavel

  Article in Periodical

  Chemico-Biological Interactions, year: 2024, volume: 397, edition: July 2024, DOI

• Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment

  AUST Anne-Christine VIDOVÁ Veronika COUFALÍKOVÁ Kateřina SMETANOVÁ Soňa KOŽELUHOVÁ Kristýna KOSEČKOVÁ MICENKOVÁ Lenka VÍDEŇSKÁ Petra SMATANA Stanislav BUDINSKÁ Eva BOREK Ivo JANKŮ Petr KLÁNOVÁ Jana SPÁČIL Zdeněk THON Vojtěch

  Article in Periodical

  Applied Microbiology and Biotechnology, year: 2024, volume: 108, edition: 1, DOI

• High-Throughput Microbore LC-MS Lipidomics to Investigate APOE Phenotypes

  GADARA Darshak Chandulal BERKA Vratislav SPÁČIL Zdeněk

  Article in Periodical

  Analytical chemistry, year: 2024, volume: 96, edition: 1, DOI

2023

• Application of the mass spectrometry to identify protein markers of Alzheimer's disease

  BUCEK Ondřej NEZVEDOVÁ Markéta SPÁČIL Zdeněk

  Conference abstract

  Year: 2023, type: Conference abstract

• Cerebral organoids derived from patients with Alzheimer´s disease with PSEN1/2 mutations have defective tissue patterning and altered development

  VÁŇOVÁ Tereza SEDMÍK Jiří RAŠKA Jan AMRUZ ČERNÁ Kateřina TAUŠ Petr POSPÍŠILOVÁ Veronika NEZVEDOVÁ Markéta FEDOROVÁ Veronika KADÁKOVÁ Soňa KLÍMOVÁ Hana CAPANDOVÁ Michaela ORVISKÁ Petra FOJTÍK Petr BÁRTOVÁ Simona PLEVOVÁ Karla SPÁČIL Zdeněk HŘÍBKOVÁ Hana BOHAČIAKOVÁ Dáša

  Article in Periodical

  CELL REPORTS, year: 2023, volume: 42, edition: 11, DOI

• Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate

  NEMERGUT Michal MARQUES Sérgio Manuel UHRÍK Lukáš VÁŇOVÁ Tereza NEZVEDOVÁ Markéta GADARA Darshak Chandulal JHA Durga TULIS Jan NOVÁKOVÁ Veronika PLANAS IGLESIAS Joan KUNKA Antonín LEGRAND Anthony Thomas P HŘÍBKOVÁ Hana POSPÍŠILOVÁ Veronika SEDMÍK Jiří RAŠKA Jan PROKOP Zbyněk DAMBORSKÝ Jiří BOHAČIAKOVÁ Dáša SPÁČIL Zdeněk HERNYCHOVÁ Lenka BEDNÁŘ David MAREK Martin

  Article in Periodical

  Molecular Neurodegeneration, year: 2023, volume: 18, edition: 1, DOI

• Effects of all-trans and 9-cis retinoic acid on differentiating human neural stem cells in vitro

  KUBÍČKOVÁ Barbara MARTINKOVÁ Šárka BOHAČIAKOVÁ Dáša NEZVEDOVÁ Markéta LIU Runze BRÓZMAN Ondřej SPÁČIL Zdeněk HILSCHEROVÁ Klára

  Article in Periodical

  Toxicology, year: 2023, volume: 487, edition: March 2023, DOI

• Pathogenesis of Alzheimer´s disease: Involvement of the choroid plexus

  ČARNA Maria ONYANGO Isaac G. KATINA Stanislav HOLUB Dušan NOVOTNY Jan Sebastian NEZVEDOVÁ Markéta JHA Durga NEDELSKA Zuzana LACOVICH Valentina VYVERE Thijs Vande HOUBRECHTS Ruben GARCIA-MANSFIELD Krystine SHARMA Ritin DAVID-DIRGO Victoria VYHNALEK Martin TEXLOVA Kateřina CHAVES Hernan BAKKAR Nadine PERTIERRA Lucia VINKLER Mojmír MARKOVA Hana LACZO Jan SHEARDOVÁ Kateřina HORTOVA-KOHOUTKOVA Marcela FRIČ Jan FORTE Giancarlo KAŇOVSKY Petr BELAŠKOVA Silvie DAMBORSKÝ Jiří HORT Jakub SEYFRIED Nicholas T. BOWSER Robert SEVLEVER Gustavo RISSMAN Robert A. SMITH Richard A. HAJDUCH Marian PIRROTTE Patrick SPÁČIL Zdeněk DAMMER Eric B. LIMBÄCK-STOKIN Clara STOKIN Gorazd B.

  Article in Periodical

  Alzheimer´s & Dementia, year: 2023, volume: 19, edition: 8, DOI