Ing. RNDr. Martin Marek, Ph.D., MBA

2020

• Structures of hyperstable ancestral haloalkane dehalogenases show restricted conformational dynamics

  BABKOVÁ Petra DUNAJOVÁ Zuzana CHALOUPKOVÁ Radka DAMBORSKÝ Jiří BEDNÁŘ David MAREK Martin

  Article in Periodical

  Computational and Structural Biotechnology Journal, year: 2020, volume: 18, edition: 2020, DOI

2019

• Functional switching based on altered enzyme flexibility via InDel mutagenesis of a reconstructed ancestor

  SCHENKMAYEROVA A. PINTO G. MAREK Martin TOUL Martin HERNYCHOVÁ Lenka LIŠKOVÁ Veronika EMOND S. BEDNÁŘ David PROKOP Zbyněk CHALOUPKOVÁ Radka HOLLFELDER F. BORNSCHEUER U.T.

  Conference abstract

  Year: 2019, type: Conference abstract

• Light-Emitting Dehalogenases: Reconstruction of Multifunctional Biocatalysts

  CHALOUPKOVÁ Radka LIŠKOVÁ Veronika TOUL Martin MARKOVÁ Klára ŠEBESTOVÁ Eva HERNYCHOVÁ Lenka MAREK Martin RANGEL PAMPLONA PIZARRO PINTO José Gaspar PLUSKAL Daniel WATERMAN Jitka PROKOP Zbyněk DAMBORSKÝ Jiří

  Article in Periodical

  ACS Catalysis, year: 2019, volume: 9, edition: 6, DOI

• One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity

  ZESSIN M. KUTIL Z. MELESHIN M. NOVAKOVA Z. GHAZY E. KALBAS D. MAREK Martin ROMIER C. SIPPL W. BARINKA C. SCHUTKOWSKI M.

  Article in Periodical

  Biochemistry, year: 2019, volume: 58, edition: 48, DOI

2018

• A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing

  SIMOBEN Conrad V. ROBAA Dina CHAKRABARTI Alokta SCHMIDTKUNZ Karin MAREK Martin LANCELOT Julien KANNAN Srinivasaraghavan MELESINA Jelena SHAIK Tajith B. PIERCE Raymond J. ROMIER Christophe JUNG Manfred SIPPL Wolfgang

  Article in Periodical

  Molecules, year: 2018, volume: 23, edition: 3, DOI

• Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants

  MAREK Martin SHAIK Tajith B. HEIMBURG Tino CHAKRABARTI Alokta LANCELOT Julien RAMOS-MORALES Elizabeth DA VEIGA Cyrielle KALININ Dmitrii MELESINA Jelena ROBAA Dina SCHMIDTKUNZ Karin SUZUKI Takayoshi HOLL Ralph ENNIFAR Eric PIERCE Raymond J. JUNG Manfred SIPPL Wolfgang ROMIER Christophe

  Article in Periodical

  Journal of Medicinal Chemistry, year: 2018, volume: 61, edition: 22, DOI

• Isoform-selective HDAC1/16/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity

  LECOINTRE Bertrand NAROZNY Remy BORRELLO Maria Teresa SENGER Johanna CHAKRABARTI Alokta JUNG Manfred MAREK Martin ROMIER Christophe MELESINA Jelena SIPPL Wolfgang BISCHOFF Laurent GANESAN A.

  Article in Periodical

  PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, year: 2018, volume: 373, edition: 1748, DOI