Nicola Silva, PhD.

2026

• Active maintenance of meiosis-specific chromosome structures in Caenorhabditis elegans by the deubiquitinase DUO-1

  STRAND Liesl G CHOI Charlotte P MCCOY Savannah NSAMBA Emmanuel T SILVA Nicola VILLENEUVE Anne M

  Article in Periodical

  Proceedings of the National Academy of Sciences of the United States of America, year: 2026, volume: 123, edition: 12, DOI

2025

• A nuclear TRiC/CCT chaperonin assembles meiotic HORMAD proteins into chromosome axes competent for crossing over

  ZETKA Monique PEZESHKI Amirhossein DAWSON Ryan HUIS IN'T VELD PIM J. JONES Steven J M SILVA Nicola

  Article in Periodical

  Nature communications, year: 2025, volume: 16, edition: 1, DOI

• Analysis of rad-51 separation of function allele suggests divergence of the synthesis-dependent strand annealing and double Holliday junction pathways prior to RAD-51 filament disassembly

  OBERLITNER Joseph TINMAN Maggie DAS Aasthika KOURY Emily SILVA Nicola SMOLIKOVE Sarit

  Article in Periodical

  Genetics, year: 2025, volume: 230, edition: 2, DOI

• Overlapping and separable activities of BRA-2 and HIM-17 promote occurrence and regulation of pairing and synapsis during Caenorhabditis elegans meiosis

  BLAŽÍČKOVÁ Jitka TRIVEDI Shalini BOWMAN Richard GEETHA Sowmya Sivakumar SUBAH Silma SCUZZARELLA Michelle CHANG Alexander CHANDRAN Uma R YANOWITZ Judith L SMOLIKOVE Sarit JANTSCH Verena ZETKA Monique SILVA Nicola

  Article in Periodical

  Nature Communications, year: 2025, volume: 16, edition: 1, DOI

2024

• Temporal Analysis of DSB Repair Outcome in Caenorhabditis elegans Meiosis

  HICKS Tara SILVA Nicola SMOLIKOVE Sarit

  Chapter of a book

  Methods in Molecular Biology, year: 2024, number of pages: 18 s.

2022

• Continuous double-strand break induction and their differential processing sustain chiasma formation during Caenorhabditis elegans meiosis

  HICKS Tara TRIVEDI Shalini EPPERT Mikayla BOWMAN Richard TIAN Hui DAFALLA Amna CRAHAN Caroline SMOLIKOVE Sarit SILVA Nicola

  Article in Periodical

  Cell Reports, year: 2022, volume: 40, edition: 13, DOI

• PARG and BRCA1-BARD1 cooperative function regulates DNA repair pathway choice during gametogenesis

  TRIVEDI Shalini BLAŽÍČKOVÁ Jitka SILVA Nicola

  Article in Periodical

  Nucleic acids research, year: 2022, volume: 50, edition: 21, DOI

• Phosphorylation of HORMA-domain protein HTP-3 at Serine 285 is dispensable for crossover formation

  DAS Debabrata TRIVEDI Shalini BLAŽÍČKOVÁ Jitka ARUR Swathi SILVA Nicola

  Article in Periodical

  G3-Genes, Genomes, Genetics, year: 2022, volume: 12, edition: 5, DOI

• Proline-specific aminopeptidase P prevents replication-associated genome instability

  SILVA Nicola CASTELLANO-POZO Maikel MATSUZAKI Kenichiro J. BARROSO Consuelo ROMAN-TRUFERO Monica P. CRAIG Hannah BROOKS Darren P. ISAAC R. Elwyn BOULTON Simon P. MARTINEZ-PEREZ Enrique

  Article in Periodical

  PLoS Genetics, year: 2022, volume: 18, edition: 1, DOI

2021

• Caenorhabditis elegans RMI2 functional homolog-2 (RMIF-2) and RMI1 (RMH-1) have both overlapping and distinct meiotic functions within the BTR complex

  VELKOVA M. SILVA Nicola DELLO STRITTO M. R. SCHLEIFFER A. BARRAUD P. HARTL M. JANTSCH V.

  Article in Periodical

  PLoS Genetics, year: 2021, volume: 17, edition: 7, DOI