2020

• CD20 is dispensable for B-cell receptor signaling but is required for proper actin polymerization, adhesion and migration of malignant B cells

  KOZLOVÁ Veronika LEDEREROVÁ Aneta LADUNGOVÁ Adriana PESCHELOVÁ Helena JANOVSKÁ Pavlína SLUSARCZYK A. DOMAGALA J. KOPČIL Pavel VAKULOVÁ Viera OPPELT Jan BRYJA Vítězslav DOUBEK Michael MAYER Jiří POSPÍŠILOVÁ Šárka ŠMÍDA Michal

  Article in Periodical

  Plos one, year: 2020, volume: 15, edition: 3, DOI

• Combination of epigenetic drug screen and CRISPR knockout screen revealed involvement of aurora kinases and Cullin 3 in CD20 regulation

  LEDEREROVÁ Aneta KOZLOVÁ Veronika MANČÍKOVÁ Veronika PESCHELOVÁ Helena PERSSON J. SCHMIERER B. DOUBEK Michael MAYER Jiří POSPÍŠILOVÁ Šárka ŠMÍDA Michal

  Conference abstract

  Year: 2020, type: Conference abstract

• Genome-wide CRISPR/Cas9 screening reveals novel target genes, whose inactivation is able to upregulate surface expression of immunotherapy target CD20

  PESCHELOVÁ Helena DOSTÁLOVÁ Lenka KOZLOVÁ Veronika LEDEREROVÁ Aneta HEJRET Václav ŠMÍDA Michal

  Conference abstract

  Year: 2020, type: Conference abstract

• Performance of anti-CD19 chimeric antigen receptor T cells in genetically defined classes of chronic lymphocytic leukemia

  MANČÍKOVÁ Veronika PESCHELOVÁ Helena KOZLOVÁ Veronika LEDEREROVÁ Aneta LADUNGOVÁ Adriana VERNER Jan LOJA Tomáš FOLBER František MAYER Jiří POSPÍŠILOVÁ Šárka ŠMÍDA Michal

  Article in Periodical

  Journal for ImmunoTherapy of Cancer, year: 2020, volume: 8, edition: 1, DOI

2019

• Elucidation of factors enhancing the expression of CD20 and thereby efficiency of CD20 monoclonal antibodies through epigenetic drug screening of resistant CLL cells

  KOZLOVÁ Veronika LEDEREROVÁ Aneta MANČÍKOVÁ Veronika MAYER Jiří POSPÍŠILOVÁ Šárka DOUBEK Michael ŠMÍDA Michal

  Conference abstract

  Year: 2019, type: Conference abstract

• Epigenetic drug screen of a CD20-low expressing cell line revealed an unexpected role of Aurora kinase inhibitors in CD20 expression.

  KOZLOVÁ Veronika LEDEREROVÁ Aneta DOUBEK Michael MAYER Jiří POSPÍŠILOVÁ Šárka ŠMÍDA Michal

  Conference abstract

  Year: 2019, type: Conference abstract

• Epigenetic drug screen of CD20-low expressing cell line revealed possible treatment target.

  KOZLOVÁ Veronika LEDEREROVÁ Aneta DOUBEK Michael MAYER Jiří POSPÍŠILOVÁ Šárka ŠMÍDA Michal

  Conference abstract

  Year: 2019, type: Conference abstract

• Epigenetic drug screen on CD20 immunotherapy resistant cells revealed possible role of Aurora kinase inhibitors in CD20 expression regulation.

  KOZLOVÁ Veronika LEDEREROVÁ Aneta MANČÍKOVÁ Veronika DOUBEK Michael MAYER Jiří POSPÍŠILOVÁ Šárka ŠMÍDA Michal

  Conference abstract

  Year: 2019, type: Conference abstract

2018

• Epigenetic drug screen of rituximab resistant cell line revealed possible treatment targets

  KOZLOVÁ Veronika LEDEREROVÁ Aneta DOUBEK Michael MAYER Jiří POSPÍŠILOVÁ Šárka ŠMÍDA Michal

  Conference abstract

  Year: 2018, type: Conference abstract

• Epigenetic drug screen on resistant CLL cells reveals Aurora kinase inhibitors as enhancers of CD20 expression and sensitizers to treatment with CD20 monoclonal antibodies

  KOZLOVÁ Veronika LEDEREROVÁ Aneta DOUBEK Michael MAYER Jiří POSPÍŠILOVÁ Šárka ŠMÍDA Michal

  Conference abstract

  Year: 2018, type: Conference abstract