RNDr. Martin Toul, Ph.D.

2023

• Catalytic mechanism for Renilla-type luciferases

  SMITH Andrea TOUL Martin PLUSKAL Daniel BAATALLAH Racha GAGNOT Glwadys RANGEL PAMPLONA PIZARRO PINTO José Gaspar SANTANA Vinicius T. T. STUCHLÁ Markéta NEUGEBAUER Petr CHAIYEN Pimchai DAMBORSKÝ Jiří BEDNÁŘ David JANIN Yves L. L. PROKOP Zbyněk MAREK Martin

  Article in Periodical

  Nature Catalysis, year: 2023, volume: 6, edition: 1, DOI

• Identification, characterization, and engineering of glycosylation in thrombolytics

  TOUL Martin SLONKOVÁ Veronika MIČAN Jan URMINSKÝ Adam Paulin TOMKOVA Maria SEDLÁK Erik BEDNÁŘ David DAMBORSKÝ Jiří HERNYCHOVÁ Lenka PROKOP Zbyněk

  Article in Periodical

  Biotechnology Advances, year: 2023, volume: 66, edition: September 2023, DOI

2022

• Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin

  NIKITIN Dmitri MIČAN Jan TOUL Martin BEDNÁŘ David PEŠKOVÁ Michaela KITTOVÁ Patrícia THALEROVÁ Sandra VÍTEČEK Jan DAMBORSKÝ Jiří MIKULÍK Robert FLEISHMAN Sarel J. PROKOP Zbyněk MAREK Martin

  Article in Periodical

  Computational and Structural Biotechnology Journal, year: 2022, volume: 20, edition: May 2022, DOI

• Extended Mechanism of the Plasminogen Activator Staphylokinase Revealed by Global Kinetic Analysis: 1000-fold Higher Catalytic Activity than That of Clinically Used Alteplase

  TOUL Martin NIKITIN Dmitri MAREK Martin DAMBORSKÝ Jiří PROKOP Zbyněk

  Article in Periodical

  ACS Catalysis, year: 2022, volume: 12, edition: 7, DOI

• Hidden Potential of Highly Efficient and Widely Accessible Thrombolytic Staphylokinase

  TOUL Martin MIČAN Jan SLONKOVÁ Veronika NIKITIN Dmitri MAREK Martin BEDNÁŘ David DAMBORSKÝ Jiří PROKOP Zbyněk

  Article in Periodical

  Stroke, year: 2022, volume: 53, edition: 10, DOI

2021

• Development and Testing of Thrombolytics in Stroke

  NIKITIN Dmitri CHOI Seungbum MIČAN Jan TOUL Martin RYU Wi-Sun DAMBORSKÝ Jiří MIKULÍK Robert KIM Dong-Eog

  Article in Periodical

  JOURNAL OF STROKE, year: 2021, volume: 23, edition: 1, DOI

• Engineering protein dynamics for the understanding of divergent evolution of the Renilla luciferase

  TOUL Martin SMITH Andrea RANGEL PAMPLONA PIZARRO PINTO José Gaspar MAREK Martin HERNYCHOVÁ Lenka LIŠKOVÁ Veronika PLUSKAL Daniel EMOND Stephane DÖRR Mark PLANAS IGLESIAS Joan CHALOUPKOVÁ Radka BEDNÁŘ David PROKOP Zbyněk BORNSCHEUER Uwe T. HOLLFELDER Florian DAMBORSKÝ Jiří

  Conference abstract

  Year: 2021, type: Conference abstract

• Engineering the protein dynamics of an ancestral luciferase

  SCHENKMAYEROVÁ Andrea RANGEL PAMPLONA PIZARRO PINTO José Gaspar TOUL Martin MAREK Martin HERNYCHOVÁ Lenka PLANAS IGLESIAS Joan LIŠKOVÁ Veronika PLUSKAL Daniel VAŠINA Michal EMOND Stephane DÖRR Mark CHALOUPKOVÁ Radka BEDNÁŘ David PROKOP Zbyněk HOLLFELDER Florian BORNSCHEUER Uwe T. DAMBORSKÝ Jiří

  Article in Periodical

  Nature Communications, year: 2021, volume: 12, edition: 1, DOI

2019

• Functional switching based on altered enzyme flexibility via InDel mutagenesis of a reconstructed ancestor

  SCHENKMAYEROVA A. PINTO G. MAREK Martin TOUL Martin HERNYCHOVÁ Lenka LIŠKOVÁ Veronika EMOND S. BEDNÁŘ David PROKOP Zbyněk CHALOUPKOVÁ Radka HOLLFELDER F. BORNSCHEUER U.T.

  Conference abstract

  Year: 2019, type: Conference abstract

• Light-Emitting Dehalogenases: Reconstruction of Multifunctional Biocatalysts

  CHALOUPKOVÁ Radka LIŠKOVÁ Veronika TOUL Martin MARKOVÁ Klára ŠEBESTOVÁ Eva HERNYCHOVÁ Lenka MAREK Martin RANGEL PAMPLONA PIZARRO PINTO José Gaspar PLUSKAL Daniel WATERMAN Jitka PROKOP Zbyněk DAMBORSKÝ Jiří

  Article in Periodical

  ACS Catalysis, year: 2019, volume: 9, edition: 6, DOI