prof. RNDr. Ondřej Slabý, Ph.D.

Curriculum Vitae

Person-Related Identification Information

• prof. RNDr. Ondřej SLABÝ, Ph.D. 15.6.1981, Brno

Department

• Department of Biology, Faculty of Medicine
  Central European Institute of Technology (CEITEC), Masaryk University, Brno

Employment - Position

• Head of Department - Department of Biology, Faculty of Medicine
  Research group leader - Central European Institute of Technology (CEITEC), Masaryk University

Education and Academic Qualifications

• 2018-2019: Harvard Medical School Postgraduate Medical Education, Cancer Biology and Therapeutics: High Impact Cancer Research Program, 1-year Certificate Program
• 2018: Professor of Medical Biochemistry, Charles University, Prague
• 2017: Elected as a Fellow of Royal Society of Biology 2016 (entitled to use designatory letters FRSB after my name)
• 2013: Associated Professor of Biochemistry, Masaryk University, Faculty of Science, Brno
• 2008: PhD (Oncology), Masaryk University, Faculty of Medicine, Brno, Dissertation thesis: „Usage of DNA microarrays and microRNA profiling in the colorectal cancer research“
• 2008: RNDr. (Biochemistry), Masaryk University, Faculty of Science, Brno, Rigorous thesis „Usage of gene expression profiles for prognosis prediction of colorectal cancer patients“
• 2005: M.Sc. (Biochemistry), Masaryk University, Faculty of Science, Brno

Employment

• 2022-to present Chairman of the Board of Czech Health Research Council
• 2022-to present Advisor of Minister of Health for Health Science and Research
• 2020-to 2021 Government Commissioner for Health Science and Research
• 2020-to present: Head, Department of Biology, Faculty of Medicine, Masaryk University
• 2011-to present: CEITEC – Research Group Leader (programme: Molecular Medicine)
• 2015-to present: Associate Professor (2015-2018), Professor (since 2018), Charles University, 1st Faculty of Medicine, Course: Molecular Medicine
• 2016: Visiting Professor at Rockefeller University, NY (Laboratory of prof. Vince Fischetti), Mar-Jun
• 2016-to present Board certification in Clinical genetics (Czech Ministry of Health)
• 2010-to present: Science Secretary of Masaryk Memorial Cancer Institute (MMCI), Brno
• 2009-to present: Research assistant, Associate Professor (since 2013), Professor (since 2018) at Department of Comprehensive Cancer Care, MMCI, Brno
• 2005-2009: research assistant, Masaryk Memorial Cancer Institute (MMCI), Department of Oncological and Experimental Pathology, Laboratory of Predictive Oncology, Brno
• 2003-2005: Diploma thesis, Laboratory of Molecular Psychiatry, Masaryk University, Faculty of Science, Brno

Teaching Activities

• professor, Masaryk University, Faculty of Medicine, Brno, course: Medical Biology I & II
• professor, Masaryk University, Faculty of Science, Brno, course: Introduction to Molecular Medicine + Practical Course
• lecturer, Charles University, 1st Faculty of Medicine, course: Molecular Medicine
• Member of the Oncological board for PhD studies at Masaryk University, Brno
• Supervisor of bachelor, master and PhD degree students - supervisor of successfully defended thesis (26 bachelor, 29 diploma, 10 PhD), supervisor of 8 active PhD students and 6 master degree students

Scientific and Research Activities

• Non-coding RNAs: their biology and involvement in carcinogenesis, their significance in solid cancer pathogenesis and identification of new therapeutic targets, their application in solid cancer diagnostics and individualization of therapy. Precision oncology.
• H-index=46, Citations without autocitations (WoS): 6800
• Intellectual Property:
• 3x international patents : PCT WO 2019/015702 (licenced by BioVendor Inc.), PCT WO 2017/019440, PCT WO 2019/060869
• 4x utility models

Internship

• 2016 (Mar-Jun): Visiting Professor at Rockefeller University, NY (Laboratory of prof. Vince Fischetti) 2022 (Jul-Aug): Visiting Scientist at Medical University Graz, Austria

University Activities

• Chair of the Biomedical Sciences Committee, PhD school, Faculty of Medicine and CEITEC, Masaryk University, Brno
• Vice-chair of the Scientific Board of Czech Minister of Health
• Member of the Scientific Board at Faculty of Medicine, Masaryk University, Brno
• Member of the Scientific Board at 1st Faculty of Medicine, Charles University, Prague
• Member of the Scientific Board at Masaryk Memorial Cancer Institute
• Member of the Oncological board for PhD studies at Masaryk University, Brno
• Member of PhD thesis Committee at Masaryk University, Brno

Activities Outside University

• Member of the Clinical and preclinical research, experimental medicine grant committee of Czech Science Foundation
• 
  
• Head of the Czechoslovak Biological Society
• Head of the Cancer Biology Section of the Czechoslovak Biological Society
• Scientific secretary of the Neurooncological section of Czech Oncological Society
• Member of: American Association for Cancer Research, European Association for Cancer Research, Czech Society of Oncology (co-founder of Neurooncology division), Member of Genetical Society of Gregor Mendel
  
  
• Associate editor Frontiers in Genetics (IF=3,3)
• Editorial Board Member: Biomarker Research (IF=4,9), Current Genomics (IF=2,2), World Journal of Gastrointestinal Oncology (IF=2.9), Non-coding RNAs, MicroRNA, Klinicka onkologie
• Peer reviewer of international journals: Nature Communications, Nature Reviews Clinical Oncology, Gut, Gastroenterology, Cancer Research, Clinical Cancer Research, European Journal of Cancer, British Journal of Cancer, Carcinogenesis...
• Ad hoc referee for grant agencies: AZV MZ ČR (Czech Health Research Council, Ministry of Health of the Czech Republic), GAČR (Czech Science Foundation), MŠMT ČR (Ministry of education, youth and sports of the Czech Republic, Cancer Research UK, WellcomeTrust, Worldwide Cancer Research (former AICR), The Netherlands ZonMw, Hungarian OTKA, Health Research Board (HRB) Ireland, Broad Medical Research Program (BMRP), VEGA SAV SK, GAUK, etc.
  
  
• Organizer of seminar, worshops and conferences: internal seminars at Masaryk Memorial Cancer Institute, Brno; member of organizing and program committee of the national conference: The Days of Diagnostic, Predictive and Experimental Oncology in Olomouc and Brněnské onkologické dny in Brno; in 2014 - president of XXI. Biological days conference, Brno

Awards Related to Science and Research

• 2010, 2012: Annual Award of the Czech Society for Oncology
• 2014: Czech Minister of Health Award
• 2015: Award of the rector of Masaryk University, Brno
• 2016: Czech Minister of Health Award
• 2017: Elected as a Fellow of Royal Society of Biology 2016 (entitled to use designatory letters FRSB after my name)
• 2017: Annual Novartis Discovery Award
• 2021: MUNI Innovation Award

Major Publications

• SLABÁ, Kateřina, Marta JEŽOVÁ, Petra POKORNÁ, Hana PÁLOVÁ, Jana TUČKOVÁ, Jan PAPEŽ, Dagmar PROCHÁZKOVÁ, Petr JABANDŽIEV a Ondřej SLABÝ. Two sisters with cardiac-urogenital syndrome secondary to pathogenic splicing variant in the MYRF gene with unaffected parents: A case of gonadal mosaicism? MOLECULAR GENETICS & GENOMIC MEDICINE. Hoboken: Wiley, roč. 11, č. 5, s. 1-7. ISSN 2324-9269. doi:10.1002/mgg3.2139. 2023. URL info
• ŠTĚRBA, Martin, Petra POKORNÁ, Renata FABEROVÁ, Blanka PINKOVÁ, Jarmila SKOTÁKOVÁ, Anna SEEHOFNEROVÁ, Jan BLATNÝ, Lucia JANIGOVÁ, Olga KOŠKOVÁ, Hana PÁLOVÁ, Michal MAHDAL, Lukáš PAZOUREK, Petr JABANDŽIEV, Ondřej SLABÝ, Peter MÚDRY a Jaroslav ŠTĚRBA. Targeted treatment of severe vascular malformations harboring PIK3CA and TEK mutations with alpelisib is highly effective with limited toxicity. Scientific reports. BERLIN: NATURE PORTFOLIO, roč. 13, č. 1, s. 1-9. ISSN 2045-2322. doi:10.1038/s41598-023-37468-4. 2023. URL info
• POKORNÁ, Petra, Giannoula KLEMENT, Alžběta VAŠÍKOVÁ, Veronika KANDEROVÁ, Marta JEŽOVÁ, Kristýna NOSKOVÁ, Peter MÚDRY, Michal KÝR, Tomáš MERTA, Viera BAJČIOVÁ, Zdenka KŘENOVÁ, Hana PÁLOVÁ, Lenka ZDRAŽILOVÁ DUBSKÁ, Ondřej SLABÝ, Dalibor VALÍK a Jaroslav ŠTĚRBA. Minimal Residual Disease–Guided Intermittent Dosing in Patients With Cancer: Successful Treatment of Chemoresistant Anaplastic Large Cell Lymphoma Using Intermittent Lorlatinib Dosing. JCO PRECISION ONCOLOGY. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS, roč. 6, June 2022, s. 1-7. ISSN 2473-4284. doi:10.1200/PO.21.00525. 2022. URL info
• LIU, I., L. JIANG, E. R. SAMUELSSON, S. MARCO SALAS, A. BECK, O. A. HACK, D. JEONG, M. L. SHAW, B. ENGLINGER, J. LABELLE, H. M. MIRE, S. MADLENER, L. MAYR, M. A. QUEZADA, M. TRISSAL, E. PANDITHARATNA, K. J. ERNST, J. VOGELZANG, T. A. GATESMAN, M. E. HALBERT, Hana PÁLOVÁ, Petra POKORNÁ, Jaroslav ŠTĚRBA, Ondřej SLABÝ, R. GEYEREGGER, A. DIAZ, I. J. FINDLAY, M. D. DUN, A. RESNICK, M. L SUVÀ., D. T. W. JONES, S. AGNIHOTRI, J. SVEDLUND, C. KOSCHMANN, C. HABERLER, T. CZECH, I. SLAVC, J. A. COTTER, K. L. LIGON, S. ALEXANDRESCU, W. K. A. YUNG, I. ARRILLAGA-ROMANY, J. GOJO, M. MONJE, M. NILSSON a M. G. FILBIN. The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location. Nature Genetics. BERLIN: NATURE PORTFOLIO, roč. 54, December 2022, s. 1881-1894. ISSN 1061-4036. doi:10.1038/s41588-022-01236-3. 2022. URL info
• GOJO, Johannes, Zdeněk PAVELKA, Danica ZAPLETALOVÁ, Maria T. SCHMOOK, Lisa MAYR, Sibylle MADLENER, Michal KÝR, Klára VEJMĚLKOVÁ, Martin SMRČKA, Thomas CZECH, Christian DORFER, Jarmila SKOTÁKOVÁ, Amedeo A. AZIZI, Monika CHOCHOLOUS, Dominik REISINGER, David LAŠTOVIČKA, Dalibor VALÍK, Christine HABERLER, Andreas PEYRL, Hana NOSKOVÁ, Karol PÁL, Marta JEŽOVÁ, Renata VESELSKÁ, Šárka KOZÁKOVÁ, Ondřej SLABÝ, Irene SLAVC a Jaroslav ŠTĚRBA. Personalized Treatment of H3K27M-Mutant Pediatric Diffuse Gliomas Provides Improved Therapeutic Opportunities. Frontiers in Oncology. Lausanne: Frontiers Media S.A., roč. 9, JAN 10 2020, s. 1-14. ISSN 2234-943X. doi:10.3389/fonc.2019.01436. 2020. URL URL info
• SLABÝ, Ondřej, Petra VYCHYTILOVÁ, Marek SVOBODA a Milana ŠACHLOVÁ. Method of diagnosis of colorectal cancer. 2020. odkaz na stránku Evropského patentového úřadu info
• MACHÁČKOVÁ, Táňa, Petra VYCHYTILOVÁ, Kamila SOUČKOVÁ, Karolína TRACHTOVÁ, Dominika BRCHNELOVÁ, Marek SVOBODA, Igor KISS, Vladimír PROCHÁZKA, Zdeněk KALA a Ondřej SLABÝ. MiR-215-5p Reduces Liver Metastasis in an Experimental Model of Colorectal Cancer through Regulation of ECM-Receptor Interactions and Focal Adhesion. Cancers. BASEL: MDPI, roč. 12, č. 12, s. 1-21. ISSN 2072-6694. doi:10.3390/cancers12123518. 2020. URL info
• CHEN, B. Q., M. P. DRAGOMIR, L. FABRIS, R. BAYRAKTAR, E. KNUTSEN, X. LIU, C. Y. TANG, Y. F. LI, T. SHIMURA, Tina CATELA IVKOVIĆ, M. C. DE LOS SANTOS, S. ANFOSSI, M. SHIMIZU, M. Y. SHAH, H. LING, P. SHEN, A. S. MULTANI, B. PARDINI, J. K. BURKS, H.. KATAYAMA, L. C. REINEKE, L. F. HUO, M. SYED, S. M. SONG, M. FERRACIN, E. OKI, B. FROMM, C. IVAN, K. BHUVANESHWAR, Y. GUSEV, K. MIMORI, D. MENTER, S. SEN, T. MATSUYAMA, H. UETAKE, C. VASILESCU, S. KOPETZ, J. PARKER-THORNBURG, A. TAGUCHI, S. M. HANASH, L. GIRNITA, Ondřej SLABÝ, A. GOEL, G. VARANI, M. GAGEA, C. L. LI, J. A. AJANI a G. A. CALIN. The Long Noncoding RNA CCAT2 Induces Chromosomal Instability Through BOP1-AURKB Signaling. Gastroenterology. Philadelphia: W B Saunders co-Elsevier Inc, roč. 159, č. 6, s. 2146-2195. ISSN 0016-5085. doi:10.1053/j.gastro.2020.08.018. 2020. URL info
• PICHLER, M., C. RODRIGUEZ-AGUAYO, SY NAM, M.P. DRAGOMIR, R. BAYRAKTAR, S. ANFOSSI, E. KNUTSEN, C. IVAN, E. FUENTES-MATTEI, S.K. LEE, H. LING, T.C. IVKOVIC, G.L. HUANG, L. HUANG, Y. OKUGAWA, H. KATAYAMA, A. TAGUCHI, E. BAYRAKTAR, R. BHATTACHARYA, P. AMERO, W.R: HE, A.M. TRAN, Petra VYCHYTILOVÁ, C. KLEC, D.L. BONILLA, X.N. ZHANG, S. KAPITANOVIC, B. LONCAR, R. GAFA, Z.H. WANG, V. CRISTINI, S.M. HANASH, M. BAR-ELI, G.N. LANZA, Ondřej SLABÝ, A. GOEL, I. RIGOUTSOS, G. LOPEZ-BERESTEIN a G.A. CALIN. Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer. Gut. LONDON: BMJ PUBLISHING GROUP, roč. 69, č. 10, s. 1818-1831. ISSN 0017-5749. doi:10.1136/gutjnl-2019-318903. 2020. URL info
• VYCHYTILOVÁ, Petra a Ondřej SLABÝ. MicroRNA-215: From biology to theranostic applications. Molecular aspects of medicine. Amsterdam: Elsevier, roč. 70, DEC, s. 72-89. ISSN 0098-2997. doi:10.1016/j.mam.2019.03.002. 2019. URL info
• ŠÁNA, Jiří, Petr BUŠEK, Pavel FADRUS, Andrej BEŠŠE, Lenka RADOVÁ, Marek VEČEŘA, Stefan REGULI, Lucie SROMOVA STOLLINOVA, Marek HILSER, Radim LIPINA, Radek LAKOMÝ, Leoš KŘEN, Martin SMRČKA, Aleksi ŠEDO a Ondřej SLABÝ. Identification of microRNAs differentially expressed in glioblastoma stem-like cells and their association with patient survival. Scientific reports. LONDON: NATURE PUBLISHING GROUP, roč. 8, FEB, s. 2836-2846. ISSN 2045-2322. doi:10.1038/s41598-018-20929-6. 2018. info
• VYCHYTILOVÁ, Petra, Jana MERHAUTOVÁ, Táňa MACHÁČKOVÁ, Irene GUTIERREZ-GARCIA, José GARCIA-SOLANO, Lenka RADOVÁ, Dominika BRCHNELOVÁ, Kateřina SLABÁ, Marek SVOBODA, Jana HALÁMKOVÁ, Regina DEMLOVÁ, Igor KISS, Rostislav VYZULA, Pablo CONESA-ZAMORA a Ondřej SLABÝ. MiR-215-5p is a tumor suppressor in colorectal cancer targeting EGFR ligand epiregulin and its transcriptional inducer HOXB9. Oncogenesis. New York, USA: Nature publishing group, roč. 6, č. 11, s. 399-412. ISSN 2157-9024. doi:10.1038/s41389-017-0006-6. 2017. URL info
• PICHLER, M., V. STIEGELBAUER, Petra VYCHYTILOVÁ, C. IVAN, H. LING, E. WINTER, X.N. ZHANG, M. GOBLIRSCH, A. WULF-GOLDENBERG, M. OHTSUKA, J. HAYBAECK, M. SVOBODA, Y. OKUGAWA, A. GERGER, G. HOEFLER, A. GOEL, Ondřej SLABÝ a G.A. CALIN. Genome-Wide miRNA Analysis Identifies miR-188-3p as a Novel Prognostic Marker and Molecular Factor Involved in Colorectal Carcinogenesis. Clinical cancer research. Philadelphia: AMER ASSOC CANCER RESEARCH, roč. 23, č. 5, s. 1323-1333. ISSN 1078-0432. doi:10.1158/1078-0432.CCR-16-0497. 2017. URL info
• STIEGELBAUER, V., Petra VYCHYTILOVÁ, M. KARBIENER, A.M. PEHSERL, A. REICHER, M. RESEL, E. HEITZER, C. IVAN, M. BULLOCK, H. LING, A. DEUTSCH, A. WULF-GOLDENBERG, J.B. ADIPRASITO, H. STOEGER, J. HAYBAECK, M. SVOBODA, M. STOTZ, G. HOEFLER, Ondřej SLABÝ, G.A. CALIN, A. GERGER a M. PICHLER. miR-196b-5p Regulates Colorectal Cancer Cell Migration and Metastases through Interaction with HOXB7 and GALNT5. Clinical cancer research. Philadelphia: AMER ASSOC CANCER RESEARCH, roč. 23, č. 17, s. 5255-5266. ISSN 1078-0432. doi:10.1158/1078-0432.CCR-17-0023. 2017. URL info
• THORENOOR, Nithyananda, Petra VYCHYTILOVÁ, Sonja HOMBACH, Jitka MLČOCHOVÁ, Markus KRETZ, Marek SVOBODA a Ondřej SLABÝ. Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer. Oncotarget. Albany: Impact Journals, roč. 7, č. 1, s. 622-637. ISSN 1949-2553. doi:10.18632/oncotarget.5807. 2016. URL info
• VYCHYTILOVÁ, Petra, Lenka RADOVÁ, Milana ŠACHLOVÁ, Zdeňka KOSAŘOVÁ, Kateřina SLABÁ, Pavel FABIAN, Tomáš GROLICH, Vladimír PROCHÁZKA, Zdeněk KALA, Marek SVOBODA, Igor KISS, Rostislav VYZULA a Ondřej SLABÝ. Serum-Based MicroRNA Signatures in Early Diagnosis and Prognosis Prediction of Colon Cancer. Carcinogenesis. Oxford: Oxford University Press, roč. 37, č. 10, s. 941-950. ISSN 0143-3334. doi:10.1093/carcin/bgw078. 2016. URL info
• MLČOCHOVÁ, Hana, Táňa MACHÁČKOVÁ, Anja RABIEN, Lenka RADOVÁ, Pavel FABIAN, Robert ILIEV, Kateřina SLABÁ, Alexandr POPRACH, Ergin KILIC, Michal STANIK, Martina LOJOVÁ, Marek SVOBODA, Jan DOLEZEL, Rostislav VYZULA, Klaus JUNG a Ondřej SLABÝ. Epithelial-mesenchymal transition-associated microRNA/mRNA signature is linked to metastasis and prognosis in clear-cell renal cell carcinoma. Scientific Reports. LONDON: NATURE PUBLISHING GROUP, roč. 6, August, s. nestránkováno, 12 s. ISSN 2045-2322. doi:10.1038/srep31852. 2016. URL info
• SLABÝ, Ondřej, Josef SROVNAL, Lenka RADOVÁ, Jan GREGAR, Jaroslav JURÁČEK, Pavla LUŽNÁ, Marek SVOBODA, Marian HAJDÚCH a Jiří EHRAMANN. Dynamic changes in microRNA expression profiles reflect progression of Barrett's esophagus to esophageal adenocarcinoma. Carcinogenesis. Oxford: Oxford University Press, roč. 36, č. 5, s. 521-527. ISSN 0143-3334. doi:10.1093/carcin/bgv023. 2015. URL info
• MLČOCHOVÁ, Jitka, Petra VYCHYTILOVÁ, Manuela FERRACIN, Barbara ZAGATTI, Lenka RADOVÁ, Marek SVOBODA, Radim NĚMEČEK, Stanislav JOHN, Igor KISS, Rostislav VYZULA, Massimo NEGRINI a Ondřej SLABÝ. MicroRNA expression profiling identifies miR-31-5p/3p as associated with time to progression in wild-type RAS metastatic colorectal cancer treated with cetuximab. Oncotarget. Albany: Impact Journals, roč. 6, č. 36, s. 38695-38704. ISSN 1949-2553. doi:10.18632/oncotarget.5735. 2015. URL info
• ŠÁNA, Jiří, Lenka RADOVÁ, Radek LAKOMÝ, Leoš KŘEN, Pavel FADRUS, Martin SMRČKA, Andrej BEŠŠE, Jana NEKVINDOVÁ, Markéta HERMANOVÁ, Radim JANČÁLEK, Marek SVOBODA, Marian HAJDÚCH, Pavel ŠLAMPA, Rostislav VYZULA a Ondřej SLABÝ. Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients. Carcinogenesis. Oxford: Oxford University Press, roč. 35, č. 12, s. 2756-2762. ISSN 0143-3334. doi:10.1093/carcin/bgu212. 2014. info
• RÉDOVÁ, Martina, Alexandr POPRACH, Jana NEKVINDOVÁ, Robert ILIEV, Lenka RADOVÁ, Radek LAKOMÝ, Marek SVOBODA, Rostislav VYZULA a Ondřej SLABÝ. Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma. Journal of Translational Medicine. London: Biomed Central, roč. 10, March, s. "nestránkováno", 8 s. ISSN 1479-5876. doi:10.1186/1479-5876-10-55. 2012. URL info
• SLABÝ, Ondřej, Marek SVOBODA, Pavel FABIAN, Tamara ŠMERDOVÁ, Dana KNOFLÍČKOVÁ, Markéta BEDNAŘÍKOVÁ, Rudolf NENUTIL a Rostislav VYZULA. Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer. Oncology. Basel: S. Karger AG, roč. 72, 5-6, s. 397-402. ISSN 0030-2414. 2008. URL info

2023/09/09