Mgr. Vladimír Rotrekl, Ph.D.

2025

• Carfilzomib-specific proteasome β5/β2 inhibition drives cardiotoxicity via remodeling of protein homeostasis and the renin-angiotensin-system

  MENDEZ-LOPEZ Max BEŠŠE Andrej ZUPPINGER Christian PEREZ-SHIBAYAMA Christian GIL-CRUZ Cristina FLOREA Bogdan I ANGELINA De Martin LUTGE Mechthild BECKEROVÁ Deborah VRANA Šimon ZHOU Xiang RASCHE Leo PŘIBYL Jan ROTREKL Vladimír LUDEWIG Burkhard OVERKLEEFT Herman S BEŠŠE Lenka DRIESSEN Christoph

  Peer-reviewed scientific article

  iScience, year: 2025, volume: 28, edition: 9, DOI

• DETEKCE ARYTMOGENÍHO POTENCIÁLU LÉČIV U DVOJICE KLASTRŮ KARDIOMYOCYTŮ S POMOCÍ MIKROSKOPIE ATOMÁRNÍCH SIL (AFM)

  PEŠL Martin SVĚRÁK Filip BECKEROVÁ Deborah VRANA Šimon KABANOV Daniil ŠČUREK Martin BRAT Kristián BÉBAROVÁ Markéta PŘIBYL Jan ROTREKL Vladimír STÁREK Zdeněk

  Conference abstract

  Year: 2025, type: Conference abstract

• Dual-Organoid Biosensor for Monitoring Cardiac Conduction Disturbances In Vitro

  MÁČALA Jakub SVĚRÁK Filip KABANOV Daniil VRANA Šimon BECKEROVÁ Deborah MÁCHAL Jan PEŠL Martin ROTREKL Vladimír PŘIBYL Jan

  Conference abstract

  Year: 2025, type: Conference abstract

• Duchenne Muscular Dystrophy cardiac organoid development: increased DNA damage, hastened maturation and elevated inflammation

  BECKEROVÁ Deborah PEŠL Martin DOBROVOLNÁ Hana KYSELÁK Ondřej ROTREKL Vladimír

  Conference abstract

  Year: 2025, type: Conference abstract

• FGF2 supports NANOG expression via pyruvate dehydrogenase-dependent histone acetylation under low oxygen conditions

  FOJTÍK Petr ŠENFLUK Martin HOLOMKOVÁ Kateřina SALYKIN Anton GREGOROVÁ Jana ŠMAK Pavel PEŠ Ondřej RAŠKA Jan BECKEROVÁ Deborah ŠTĚTKOVÁ Monika SKLÁDAL Petr SEDLÁČKOVÁ Miroslava HAMPL Aleš BOHAČIAKOVÁ Dáša ULDRIJAN Stjepan ROTREKL Vladimír

  Peer-reviewed scientific article

  Frontiers in Cell and Developmental Biology, year: 2025, volume: 13, edition: October 2025, DOI

• Protective role of salbutamol against aminophylline-induced arrhythmias in an hPSC-based cardiac model

  SCUREK Martin KABANOV Daniil KLIMOVIC Simon BECKEROVA Deborah PEŠL Martin PRIBYL Jan BÉBAROVÁ Markéta ROTREKL Vladimír BRAT Kristian

  Paper in proceedings

  EUROPEAN RESPIRATORY JOURNAL, year: 2025, DOI

• SALBUTAMOL ATTENUATES THE ARRHYTHMOGENIC EFFECT OF AMINOPHYLLINE IN CARDIAC ORGANOIDS EXPERIMENTAL MODEL (AFM Bio Med 2025)

  PEŠL Martin KABANOV Daniil VRANA Šimon BECKEROVÁ Deborah ŠČUREK Martin BRAT Kristián BÉBAROVÁ Markéta ROTREKL Vladimír PŘIBYL Jan

  Conference abstract

  Year: 2025, type: Conference abstract

2024

• Computer-aided engineering of stabilized fibroblast growth factor 21

  DE LA BOURDONNAYE Gabin GHAZALOVÁ Tereza FOJTÍK Petr KUTALKOVA Katerina BEDNÁŘ David DAMBORSKÝ Jiří ROTREKL Vladimír STEPANKOVA Veronika CHALOUPKOVÁ Radka

  Peer-reviewed scientific article

  Computational and Structural Biotechnology Journal, year: 2024, volume: 23, edition: December 2024, DOI

• Hyaluronic acid-based hydrogels with tunable mechanics improved structural and contractile properties of cells

  KLIMOVIČ Šimon BECKEROVÁ Deborah VĚŽNÍK Jakub KABANOV Daniil LACINA Karel JELÍNKOVÁ Šárka GUMULEC Jaromír ROTREKL Vladimír PŘIBYL Jan

  Peer-reviewed scientific article

  Biomaterials Advances, year: 2024, volume: 159, edition: May 2024, DOI

• Microphysiological Analysis of Cardiomyocyte Function in 3D Organoids

  PEŠL Martin SVĚRÁK Filip KABANOV Daniil KLIMOVIČ Šimon BECKEROVÁ Deborah ROTREKL Vladimír PŘIBYL Jan

  Conference abstract

  Year: 2024, type: Conference abstract