Publication details

Application on nanoparticles in desorption mass spectrometry

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Year of publication 2012
Type Conference abstract
MU Faculty or unit

Central European Institute of Technology

Description Nanomaterials can serve as an alternative to matrix-assisted laser desorption/ionization (MALDI) matrix for the analysis of numerous analytes. This lecture will give a brief overview of nanoparticles used in the process called surface-assisted laser desorption/ionization mass spectrometry (SALDI MS). Selected applications of gold nanoparticles (AuNPs) in SALDI MS will be presented to demostrate the potential and limitations of SALDI MS. AuNPs were used as s matrix for quantitative analysis of melamine in infant formula and grain powder and glutathione in grape leaves. Although quantitative analyses using SALDI MS without any internal standard is possible, use of internal of the internal standard for quantitative analysis is strongly advised. In the last example, SALDI-MS serves as a useful tool to examine the reaction process. In this case, AuNPs served as an efficient SALDI substrate to monitor redox reactions during nanoparticle formation process.
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